Clinical Study Support, Inc., Nagoya, 460-0003, Japan.
Department of Public Health, Aichi Medical University School of Medicine, Nagakute, 480-1195, Japan.
Sci Rep. 2017 Jan 16;7:40363. doi: 10.1038/srep40363.
Colorectal cancer is the third most common cancer worldwide, and many risk factors for colorectal cancer have been established. However, it remains uncertain whether psychological stress contributes to the onset of colorectal cancer. Therefore, we conducted a large-scale prospective cohort study to confirm the association between perceived stress and colorectal cancer incidence. We identified 680 cases of colon cancer and 330 cases of rectal cancer during a maximum of 21-year follow-up of 61,563 Japanese men and women. Cox regression analysis adjusted for potential confounders revealed a significant association of perceived stress with rectal cancer incidence but not with colon cancer incidence. This finding is partly consistent with that from only one previous study that addressed an association between perceived stress and the risk of colorectal cancer. However, studies on this topic are sparse and warrant further exploration.
结直肠癌是全球第三大常见癌症，许多结直肠癌的风险因素已得到确立。然而，心理压力是否会导致结直肠癌的发生仍不确定。因此，我们进行了一项大规模的前瞻性队列研究，以证实感知压力与结直肠癌发病率之间的关联。在对 61563 名日本男性和女性进行的最长 21 年的随访中，我们确定了 680 例结肠癌和 330 例直肠癌病例。对潜在混杂因素进行调整的 Cox 回归分析显示，感知压力与直肠癌的发生显著相关，但与结肠癌的发生无关。这一发现与之前一项仅研究感知压力与结直肠癌风险之间关联的研究部分一致。然而，关于这一主题的研究很少，需要进一步探索。
