Kennedy Eleanor, Cohen Miriam, Munafò Marcus
MRC Integrative Epidemiology Unit at the University of Bristol, UK Centre for Tobacco and Alcohol Studies, School of Experimental Psychology, University of Bristol, United Kingdom (Ms Kennedy and Dr Munafò); and College of Life and Environmental Sciences, University of Exeter, United Kingdom (Ms Cohen).
J Head Trauma Rehabil. 2017 Nov/Dec;32(6):425-432. doi: 10.1097/HTR.0000000000000289.
To systematically review the evidence that childhood traumatic brain injury (TBI) is associated with risk behavior in adolescence and young adulthood. Risk behavior included one or more of the following: use of substances, including alcohol, tobacco, and illicit substances; involvement in criminal behavior; and behavioral issues with conduct.
A literature search was conducted using these terms: child, pediatric, traumatic brain injury, head injury, adolescent, psychosocial, antisocial, conduct, substance use. Studies describing original research were included if they reported outcomes over the age of 13 years in participants who sustained a TBI between birth and age 13 years.
Six journal articles were reviewed based on 4 separate studies. Three articles indicated a relationship between childhood TBI and increased problematic substance use in adolescence and young adulthood. Three articles supported an association between childhood TBI and later externalizing behavior; however, 2 articles did not support this link.
More research is warranted to explore the association between childhood TBI and later risk behavior as the relationship is not currently understood. Future research should build on existing longitudinal research with continued use of medical records for identifying TBI and inclusion of a non-brain-related trauma group to control for general injury effects.
系统回顾儿童创伤性脑损伤（TBI）与青少年及青年期风险行为之间存在关联的证据。风险行为包括以下一项或多项：使用物质，包括酒精、烟草和非法药物；参与犯罪行为；以及行为方面的品行问题。
使用以下术语进行文献检索：儿童、儿科、创伤性脑损伤、头部损伤、青少年、心理社会、反社会、品行、物质使用。如果研究报告了出生至13岁期间遭受TBI的参与者在13岁以上的结果，则纳入描述原始研究的研究。
基于4项独立研究对6篇期刊文章进行了综述。3篇文章表明儿童TBI与青少年及青年期问题物质使用增加之间存在关联。3篇文章支持儿童TBI与后期外化行为之间存在关联；然而，2篇文章不支持这种联系。
鉴于目前尚不清楚儿童TBI与后期风险行为之间的关系，有必要进行更多研究来探索两者之间的关联。未来的研究应在现有纵向研究的基础上继续进行，持续使用医疗记录来识别TBI，并纳入一个非脑相关创伤组以控制一般损伤影响。
