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用于研究抗氧化活性的细胞和动物模型评估:综述

Evaluation of the Cellular and Animal Models for the Study of Antioxidant Activity: A Review.

作者信息

Zhang Huijuan, Yin Meng, Huang Lianyan, Wang Jing, Gong Lingxiao, Liu Jie, Sun Baoguo

机构信息

Innovation Center for Food Nutrition and Human Health, Beijing Technology & Business Univ. (BTBU), Beijing, 100048, China.

Beijing Engineering and Technology Research Center of Food Additives, Beijing, 100048, China.

出版信息

J Food Sci. 2017 Feb;82(2):278-288. doi: 10.1111/1750-3841.13605. Epub 2017 Jan 24.

DOI:10.1111/1750-3841.13605
PMID:28117894
Abstract

The mechanisms of antioxidant activities of phytochemicals are highly complex, so various methods to study them have been developed. However, the diverse available methods show inconsistent results. Different stressors, cell models, and animal models have been used to evaluate the antioxidant properties of phytochemicals. However, the literature still lacks a summary of the effects of different stressors, cell models, and animal models on the evaluation of antioxidant activities. Therefore, the mechanisms of action of different oxidative stimuli and the characteristics of the available cell models and animal models are summarized in this review.

摘要

植物化学物质抗氧化活性的机制非常复杂,因此已经开发了各种方法来研究它们。然而,现有的各种方法显示出不一致的结果。不同的应激源、细胞模型和动物模型已被用于评估植物化学物质的抗氧化特性。然而,文献中仍然缺乏关于不同应激源、细胞模型和动物模型对抗氧化活性评估影响的总结。因此,本综述总结了不同氧化刺激的作用机制以及可用细胞模型和动物模型的特点。

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