Akmatov Manas K, Jentsch Leonhard, Riese Peggy, May Marcus, Ahmed Malik W, Werner Damaris, Rösel Anja, Prokein Jana, Bernemann Inga, Klopp Norman, Prochnow Blair, Illig Thomas, Schindler Christoph, Guzman Carlos A, Pessler Frank
TWINCORE, Centre for Experimental and Clinical Infection Research, Hannover, Germany.
Helmholtz Centre for Infection Research, Braunschweig, Germany.
BMC Med Res Methodol. 2017 Feb 2;17(1):18. doi: 10.1186/s12874-017-0302-z.
Participation in epidemiological studies has strongly declined in recent years. We examined the reasons for (non)participation in population-based health studies among participants and nonparticipants of a prospective study on influenza vaccination among the elderly.
Males and females between 65 and 80 years of age (N = 5582) were randomly selected from the residents' registration office in Hannover, Germany, and were invited to participate in a study featuring vaccination with a seasonal adjuvanted influenza vaccine (Fluad™, Novartis) including five follow-up visits (day 0, 1/3, 7, 21, 70 with respect to vaccination). A 24-item nonresponder questionnaire, including 10 items on reasons for participating in a hypothetical health study, was mailed to 1500 randomly selected nonparticipants. The same 10 items were included in the end-of-study questionnaire administered to the participants in the vaccination study (n = 200). Logistic regression analysis with backward elimination was used to identify the reasons most strongly associated with nonparticipation.
Five hundred thirty-one (35%) nonparticipants and 200 participants (100%) returned the respective questionnaires. Nonparticipation was associated with a lower interest in obtaining personal health information (OR = 3.32) and a preference for less invasive (OR = 3.01) and less time-demanding (OR = 2.19) studies. Responses to other items, e.g. regarding altruistic motives, monetary compensation, general interest of the study, or study approval through ethics committee and data security authority, did not differ between participants and nonparticipants.
Participation rates in health studies among elderly individuals could potentially be improved by reducing interventions and time demand, for instance by implementing methods of self-sampling and remote data collection.
No. 1100359 (ClinicalTrials.gov, date of registration: 09.02.2015).
近年来，参与流行病学研究的人数大幅下降。我们调查了一项针对老年人流感疫苗接种的前瞻性研究的参与者和非参与者参与（或不参与）基于人群的健康研究的原因。
从德国汉诺威居民登记处随机选取65至80岁的男性和女性（N = 5582），邀请他们参与一项使用季节性佐剂流感疫苗（Fluad™，诺华公司）进行接种的研究，包括五次随访（接种当天、第1/3天、第7天、第21天、第70天）。向1500名随机选取的非参与者邮寄了一份包含24个项目的无应答问卷，其中包括10个关于参与假设性健康研究原因的项目。接种研究的参与者（n = 200）在研究结束时的问卷中也包含了相同的10个项目。采用向后逐步回归的逻辑回归分析来确定与不参与最密切相关的原因。
531名（35%）非参与者和200名参与者（100%）返回了各自的问卷。不参与与获取个人健康信息的兴趣较低（OR = 3.32）以及倾向于侵入性较小（OR = 3.01）和耗时较少（OR = 2.19）的研究有关。对于其他项目的回答，例如关于利他动机、金钱补偿、研究的总体兴趣或伦理委员会和数据安全机构对研究的批准，参与者和非参与者之间没有差异。
通过减少干预措施和时间需求，例如采用自我采样和远程数据收集方法，有可能提高老年人健康研究的参与率。
第1100359号（ClinicalTrials.gov，注册日期：2015年2月9日）。
