Department of Chemistry, Maharishi Markandeshwar University, Mullana, Ambala-133207, Haryana, India.
Mini Rev Med Chem. 2018;18(15):1270-1282. doi: 10.2174/1389557517666170208143410.
Inflammation plays an important role in maintaining the body's homeostasis. It repairs the damaged tissues of the body resulting from injury or infection. In addition, a diverse array of diseases like hepatitis, arthritis and colitis has been reported and described to be associated with inflammatory processes. Some autoimmune diseases like inflammatory bowel disease (IBD) emerge by the influence of numerous genes in complex environmental situations belong to inflammation. The currently available processes for curing inflammation and related disorders facilitate the use of non steroidal antiinflammatory drugs (NSAIDs). Moreover, intolerable side effects are also associated with the consumption of these medications. It is well known that phenolic compounds, largely present in vegetables and fruits, serve as an integral part of normal human diet besides having great medicinal value. These are considered to reflect a variety of anti-inflammatory properties, and can be used as an alternate natural source for the prevention of chronic inflammatory disorders. This mini-review summarized the antiinflammatory benefits of plants derived very prominent dietary polyphenolic compounds particularly, Oleocanthal, Curcumin, Resveratrol and Quercetin.
炎症在维持身体内环境平衡中起着重要作用。它修复了因受伤或感染而受损的身体组织。此外，已有多种疾病，如肝炎、关节炎和结肠炎，被报道并描述为与炎症过程有关。一些自身免疫性疾病，如炎症性肠病 (IBD)，是由复杂环境条件下众多基因的影响引起的，属于炎症范畴。目前用于治疗炎症和相关疾病的方法促进了非甾体抗炎药（NSAIDs）的使用。此外，这些药物的使用还会产生不可耐受的副作用。众所周知，酚类化合物大量存在于蔬菜和水果中，除了具有巨大的药用价值外，还是人类正常饮食的重要组成部分。这些被认为反映了多种抗炎特性，并可用作预防慢性炎症性疾病的天然替代来源。本综述总结了源自植物的具有显著抗炎作用的膳食多酚类化合物，特别是橄榄苦苷、姜黄素、白藜芦醇和槲皮素的抗炎作用。
