视盘相关参数对眼底照片视网膜血管直径测量结果的影响。
Effects of optic nerve head-related parameters on retinal vessel calibers measurement results on fundus photographs.
机构信息
Tajimi Iwase Eye Clinic, 3-101-1, Hon-machi, Tajimi, Gifu Prefecture, Tajimi, 507-0033, Japan.
Tsutsumi Eye Clinic, Nerima-ku, Tokyo, Japan.
出版信息
BMC Ophthalmol. 2022 May 12;22(1):215. doi: 10.1186/s12886-022-02428-5.
BACKGROUND
Although relationship between the retinal vessel caliber (RVC) and glaucoma is well known, there has been a paucity of information on the effects of glaucoma-related optic nerve head (ONH) structural factors on the RVC. Information on this relationship should be useful in studying possible roles of ocular circulation in the development and progression of glaucoma.
METHOD
Subjects were from Kumejima Study participants aged 40 years and older in Kumejima, Japan. Normal subjects and eyes were defined according to standardized systemic and ocular examinations. The central retinal artery and vein equivalents (CRAE and CRVE) were determined on fundus photographs by correcting the magnification using the refractive error, corneal curvature, and axial length (AL) of an individual eye and paraxial ray tracing; the ONH structural parameters were determined by planimetry.
RESULTS
In a total of 558 right eyes (558 normal subjects), aged 49.0 ± 7.1 (standard deviation) years with gradable photographs and planimetric results, CRAE averaged 136.1 ± 12.3 μm and CRVE 216.9 ± 17.4 μm. After adjustment for the effects of confounding factors in multivariate analysis, the AL (P < 0.001), rim area (P = 0.019), disc area (P = 0.042), and smoking (P = 0.035-0.043) correlated positively, and the mean blood pressure (P < 0.001) negatively with CRAE; the AL (P < 0.001), rim area (P = 0.001), disc area (P = 0.005), smoking (P < 0.001), and male sex (P = 0.013) correlated positively, and the β-peripapillary atrophy (β-PPA) area (P = 0.044), vertical Cup/Disc ratio (v-C/D) (P = 0.035), and age (P < 0.001) negatively with CRVE.
CONCLUSION
The current study showed significant effects of rim area, v-C/D or β-PPA area determined on the photographs on the RVC measurement results. Further, it showed a necessity to incorporate the glaucoma-related ONH structural parameters as co-variables to correctly estimate the effects of various factors on the RVC.
背景
尽管视网膜血管口径（RVC）与青光眼之间的关系已为人熟知，但有关青光眼相关视神经头（ONH）结构因素对 RVC 的影响的信息却很少。了解这种关系有助于研究眼部循环在青光眼发展和进展中的可能作用。
方法
本研究对象为日本久米岛研究的 40 岁及以上参与者。根据标准化的全身和眼部检查，将正常受试者和眼部定义为正常。通过使用个体眼的屈光不正、角膜曲率和眼轴（AL）校正放大倍数，并使用傍轴光线追踪法，在眼底照片上确定中央视网膜动脉和静脉当量（CRAE 和 CRVE）；通过平面测量法确定 ONH 结构参数。
结果
在总共 558 只右眼（558 名正常受试者）中，年龄为 49.0±7.1（标准差）岁，照片和平面测量结果可分级，CRAE 的平均值为 136.1±12.3μm，CRVE 为 216.9±17.4μm。在多变量分析中调整混杂因素的影响后，AL（P<0.001）、边缘面积（P=0.019）、盘面积（P=0.042）和吸烟（P=0.035-0.043）与 CRAE 呈正相关，平均血压（P<0.001）与 CRAE 呈负相关；AL（P<0.001）、边缘面积（P=0.001）、盘面积（P=0.005）、吸烟（P<0.001）和男性（P=0.013）与 CRVE 呈正相关，而β-视盘旁萎缩（β-PPA）面积（P=0.044）、垂直杯盘比（v-C/D）（P=0.035）和年龄（P<0.001）与 CRVE 呈负相关。
结论
本研究表明，照片上的边缘面积、v-C/D 或 β-PPA 面积对 RVC 测量结果有显著影响。此外，还表明需要将与青光眼相关的 ONH 结构参数作为协变量纳入，以正确估计各种因素对 RVC 的影响。
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