Huang Ang, Chang Binxia, Sun Yin, Lin Huiming, Li Baosen, Teng Guangju, Zou Zheng-Sheng
Center of Noninfectious Liver Diseases, Beijing 302 Hospital Institute of Alcoholic Liver Disease, Beijing 302 Hospital, Beijing, China.
Medicine (Baltimore). 2017 Feb;96(7):e6163. doi: 10.1097/MD.0000000000006163.
Alcohol consumption in China has substantially increased over the last 3 decades and the number of patients with alcoholic liver disease (ALD) is rising at an alarming rate. However, accurate and representative data on time trends in its hospitalization rates are not available. The aim of this study is to assess the current status and burden of ALD in China by analyzing the data from a large tertiary referral hospital, Beijing 302 Hospital.Data were retrospectively recorded from patients diagnosed as ALD in Beijing 302 Hospital from 2002 to 2013. The disease spectrum and biochemical parameters of each patient were collected.The patients with ALD accounted for 3.93% (7422) of all patients (188,902) with liver diseases between 2002 and 2013. The number of patients hospitalized with ALD increased from 110 in 2002 to 1672 in 2013. The ratio of patients hospitalized with ALD to all patients hospitalized with liver diseases was rising almost continuously and increased from 1.68% in 2002 to 4.59% in 2013. Most patients with ALD were male. Age distribution of ALD hospitalization showed that the highest rate was in 40- to 49-year-old group in subjects. Notably, the annual proportion of severe alcoholic hepatitis (SAH) increased 2.43 times from 2002 to 2013. We found the highest levels of mean corpuscular volume, the aspartate aminotransferase/alanine aminotransferase ratio, total bilirubin, international normalized ratio, and alkaline phosphatase in SAH patients, while serum levels of hemoglobin, albumin, and cholinesterase were significantly decreased in SAH group. Among these ALD, the SAH patient population has the worst prognosis. Alcoholic cirrhosis (ALC) is the most common ALD, and annual admissions for ALC increased significantly during the analyzed period.The number of hospitalized patients with ALD and the annual hospitalization rate of ALD were increasing continuously in Beijing 302 Hospital from 2002 to 2013. More attention should be paid to develop population-based effective strategy to control ALD.
在过去三十年中，中国的酒精消费量大幅增加，酒精性肝病（ALD）患者数量正以惊人的速度上升。然而，目前尚无关于其住院率时间趋势的准确且具代表性的数据。本研究旨在通过分析来自大型三级转诊医院——北京302医院的数据，评估中国ALD的现状及负担。
数据回顾性记录了2002年至2013年在北京302医院被诊断为ALD的患者情况。收集了每位患者的疾病谱和生化参数。
2002年至2013年间，ALD患者占所有肝病患者（188,902例）的3.93%（7422例）。ALD住院患者数量从2002年的110例增加到2013年的1672例。ALD住院患者与所有肝病住院患者的比例几乎持续上升，从2002年的1.68%增至2013年的4.59%。大多数ALD患者为男性。ALD住院患者的年龄分布显示，40至49岁年龄组的发病率最高。值得注意的是，2002年至2013年期间，严重酒精性肝炎（SAH）的年度比例增长了2.43倍。我们发现SAH患者的平均红细胞体积、天冬氨酸转氨酶/丙氨酸转氨酶比值、总胆红素、国际标准化比值和碱性磷酸酶水平最高，而SAH组的血红蛋白、白蛋白和胆碱酯酶血清水平显著降低。在这些ALD患者中，SAH患者群体的预后最差。酒精性肝硬化（ALC）是最常见的ALD类型，在分析期间，ALC的年度入院人数显著增加。
2002年至2013年期间，北京302医院ALD住院患者数量和ALD年度住院率持续上升。应更加重视制定基于人群的有效策略来控制ALD。
