翅麻黄的局部水提取物可改善动物模型中的伤口愈合。
Topical aqueous extract of Ephedra alata can improve wound healing in an animal model.
作者信息
Kittana Naim, Abu-Rass Hanood, Sabra Ruba, Manasra Lama, Hanany Hadeel, Jaradat Nidal, Hussein Fatima, Zaid Abdel Naser
机构信息
Department of Biomedical Sciences, Faculty of Medicine & Health Sciences, An-Najah National University, Nablus - P.O. Box 7, Palestine.
Department of Biomedical Sciences, Faculty of Medicine & Health Sciences, An-Najah National University, Nablus - P.O. Box 7, Palestine.
出版信息
Chin J Traumatol. 2017 Apr;20(2):108-113. doi: 10.1016/j.cjtee.2016.10.004. Epub 2017 Jan 20.
PURPOSE
Ephedra alata (E. alata) is perennial tough shrub plant that grows in Palestine and other regions. It is used often in folk's medicine for the treatment of various diseases. In this project, E. alata extract was tested for its ability to improve wound and burn healing.
METHODS
An aqueous extract of E. alata was prepared and underwent several phytochemical analyses for the presence of the major classes of phytochemical compounds. After that, a polyethylene glycol-based ointment containing the extract of E. alata was prepared and its wound and burn healing activities were tested in-vivo using an animal model for deep wound and full thickness skin burn. The effect was compared against a placebo ointment. Skin biopsies were evaluated by a blinded clinical histopathologist, in addition to digital analysis.
RESULTS
Phytochemical analysis demonstrated the presence of the major classes of phytochemical compounds in the prepared extract including flavonoids, alkaloids, phytosteroids, phenolic compounds, volatile oils and tannins. As compared to placebo ointment, E. alata ointment significantly improved the healing of the wound ulcers, whereas it showed no advantage on the quality of the healing of burn ulcers.
CONCLUSION
E. alata extract is rich in phytochemical compounds and can improve wound healing when applied topically.
目的
翼麻黄是一种多年生坚韧灌木植物，生长于巴勒斯坦及其他地区。它在民间医学中常被用于治疗各种疾病。在本项目中，对翼麻黄提取物促进伤口和烧伤愈合的能力进行了测试。
方法
制备了翼麻黄水提取物，并对其主要类别的植物化学化合物进行了多项植物化学分析。之后，制备了一种含翼麻黄提取物的聚乙二醇基软膏，并使用深部伤口和全层皮肤烧伤动物模型在体内测试其伤口和烧伤愈合活性。将效果与安慰剂软膏进行比较。除了数字分析外，由一位不知情的临床组织病理学家对皮肤活检进行评估。
结果
植物化学分析表明，制备的提取物中存在主要类别的植物化学化合物，包括黄酮类、生物碱、植物甾醇、酚类化合物、挥发油和单宁。与安慰剂软膏相比，翼麻黄软膏显著改善了伤口溃疡的愈合，而在烧伤溃疡愈合质量方面未显示出优势。
结论
翼麻黄提取物富含植物化学化合物，局部应用时可促进伤口愈合。
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