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DNA damage responses in central nervous system and age-associated neurodegeneration.

作者信息

Hegde Muralidhar L, Bohr Vilhelm A, Mitra Sankar

机构信息

Department of Radiation Oncology, Houston Methodist Research Institute, Houston, TX 77030, USA; Houston Methodist Neurological Institute, Houston, TX 77030, USA; Weill Medical College of Cornell University, New York, USA.

Laboratory of Molecular Gerontology, National Institute on Aging, NIH, Baltimore, MD 21224, USA.

出版信息

Mech Ageing Dev. 2017 Jan;161(Pt A):1-3. doi: 10.1016/j.mad.2017.01.010.

DOI:10.1016/j.mad.2017.01.010
PMID:28212866
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5458627/
Abstract
摘要

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Genomic integrity and the ageing brain.基因组完整性与衰老大脑。
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Physiologic brain activity causes DNA double-strand breaks in neurons, with exacerbation by amyloid-β.生理脑活动导致神经元中的 DNA 双链断裂，淀粉样β蛋白加剧了这种情况。
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Age-related neuronal degeneration: complementary roles of nucleotide excision repair and transcription-coupled repair in preventing neuropathology.年龄相关性神经元退行性变：核苷酸切除修复和转录偶联修复在预防神经病理学中的互补作用。
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