Garth Jaleesa M, Steele Chad
Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
J Innate Immun. 2017;9(3):271-280. doi: 10.1159/000455125. Epub 2017 Feb 24.
Invasive aspergillosis (IA) is one of the most difficult to treat and, consequently, one of the most lethal fungal infections known to man. Continued use of immunosuppressive agents during chemotherapy and organ transplantation often leads to the development of neutropenia, the primary risk factor for IA. However, IA is also becoming more appreciated in chronic diseases associated with corticosteroid therapy. The innate immune response to Aspergillus fumigatus, the primary agent in IA, plays a pivotal role in the recognition and elimination of organisms from the pulmonary system. This review highlights recent findings about innate host defense mechanisms, including novel aspects of innate cellular immunity and pathogen recognition, and the inflammatory mediators that control infection with A. fumigatus.
侵袭性曲霉病(IA)是最难治疗的疾病之一,因此也是人类已知的最致命的真菌感染之一。化疗和器官移植期间持续使用免疫抑制剂常常导致中性粒细胞减少症的发生,这是IA的主要危险因素。然而,IA在与皮质类固醇治疗相关的慢性疾病中也越来越受到重视。对IA的主要病原体烟曲霉的固有免疫反应在识别和清除肺部系统中的病原体方面起着关键作用。本综述重点介绍了关于固有宿主防御机制的最新发现,包括固有细胞免疫和病原体识别的新方面,以及控制烟曲霉感染的炎症介质。