Sundberg Kay, Wengström Yvonne, Blomberg Karin, Hälleberg-Nyman Maria, Frank Catharina, Langius-Eklöf Ann
Department of NVS, Division of Nursing, Karolinska Institutet, 23 300, Huddinge, 14183, Stockholm, Sweden.
Radiumhemmet, Karolinska University Hospital, Stockholm, Sweden.
Support Care Cancer. 2017 Jul;25(7):2195-2204. doi: 10.1007/s00520-017-3625-8. Epub 2017 Feb 24.
Patients undergoing radiotherapy for prostate cancer suffer from a variety of symptoms which influence health-related quality of life. We have developed an application (Interaktor) for smartphones and tablets for early detection, reporting and management of symptoms, and concerns during treatment for prostate cancer. The study evaluates the effect on symptom burden and quality of life when using the application for real-time symptom assessment and management during radiotherapy for localized prostate cancer.
A non-randomized controlled study was used at two university hospitals in Sweden where 64 patients constituted a control group and 66 patients made up an intervention group. The intervention group was asked to report symptoms via the application daily during the treatment as well as 3 weeks after. The EORTC QLQ-C30 and its module PR25 and the Sense of Coherence questionnaire were administered at three time points in both groups.
The intervention group rated significantly lower levels of fatigue and nausea at the end of radiotherapy. Moreover, they had significantly less burden in emotional functioning, insomnia, and urinary-related symptoms at the end of treatment as well as 3 months later compared with the control group. In the multivariate analyses, with education and sense of coherence as covariates, the intervention group still significantly rated emotional functioning (p = 0.007), insomnia (p = 0.017), and urinary-related symptoms (p = 0.008) as better than the control group at T2.
Study findings suggest that Interaktor could be an efficient mHealth tool for facilitating supportive care needs during cancer treatment.
接受前列腺癌放疗的患者会出现多种影响健康相关生活质量的症状。我们开发了一款适用于智能手机和平板电脑的应用程序(Interaktor),用于前列腺癌治疗期间症状、担忧的早期检测、报告及管理。本研究评估了在局限性前列腺癌放疗期间使用该应用程序进行实时症状评估和管理时,对症状负担和生活质量的影响。
在瑞典的两家大学医院进行了一项非随机对照研究,其中64名患者组成对照组,66名患者组成干预组。干预组被要求在治疗期间及治疗后3周每天通过该应用程序报告症状。两组在三个时间点均进行了欧洲癌症研究与治疗组织生活质量核心问卷(EORTC QLQ-C30)及其前列腺癌模块(PR25)以及连贯感问卷的调查。
干预组在放疗结束时疲劳和恶心程度的评分显著更低。此外,与对照组相比,他们在治疗结束时以及3个月后在情绪功能、失眠和泌尿系统相关症状方面的负担明显更小。在多变量分析中,以教育程度和连贯感作为协变量,干预组在T2时情绪功能(p = 0.007)、失眠(p = 0.017)和泌尿系统相关症状(p = 0.008)的评分仍显著优于对照组。
研究结果表明,Interaktor可能是一种有效的移动健康工具,有助于满足癌症治疗期间的支持性护理需求。