Arconada-Alvarez Santiago J, Lemaster Jeanne E, Wang Junxin, Jokerst Jesse V
Department of NanoEngineering, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92092, USA.
Photoacoustics. 2017 Feb 10;5:17-24. doi: 10.1016/j.pacs.2017.02.001. eCollection 2017 Mar.
We report a new approach to preparing phantoms using 3D printing. This device supports plastic tubing containing the contrast agent and is immersed in a solution with absorption or scattering properties that mimic tissue. Up to 12 tubing samples could be placed in the device with sample-to-sample spacing as low as 0.3 mm and at a constant distance from the transducer (±0.16 mm), which is critical in validating photoacoustic contrast agents. We also studied different types of tubing and found that tubing with a larger outside diameter has more inherent signal. Both 40% India Ink and lipids in the immersion media modulated the signal. Finally, we created a depth phantom and found that signal decayed following a linear relationship (R = 0.997) with respect to distance from the focal point. We include computer-assisted drafting code the community can use to print this phantom or customized versions of this phantom.
我们报告了一种使用3D打印制备体模的新方法。该装置支撑着装有造影剂的塑料管道，并将其浸入具有模拟组织吸收或散射特性的溶液中。该装置中最多可放置12个管道样本，样本间距低至0.3毫米，且与换能器保持恒定距离（±0.16毫米），这对于验证光声造影剂至关重要。我们还研究了不同类型的管道，发现外径较大的管道具有更强的固有信号。浸入介质中的40%印度墨水和脂质均能调节信号。最后，我们制作了一个深度体模，发现信号相对于距焦点的距离呈线性关系衰减（R = 0.997）。我们提供了计算机辅助绘图代码，社区可以使用该代码来打印此体模或其定制版本。
