Vogel Rachel Isaksson, Strayer Lori G, Engelman Leah, Nelson Heather H, Blaes Anne H, Anderson Kristin E, Lazovich DeAnn
Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Women's Health, University of Minnesota, 420 Delaware Street SE, MMC 395, Minneapolis, MN, 55455, USA.
Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.
Qual Life Res. 2017 Jul;26(7):1761-1766. doi: 10.1007/s11136-017-1532-6. Epub 2017 Feb 27.
Little is known about specific concerns facing long-term melanoma survivors. The goal of this study was to compare quality of life (QOL) and mental health between long-term melanoma survivors and population controls.
Participants from a previously conducted case-control study of risk factors for melanoma were recruited for a cross-sectional survey. Generic QOL and emotional health were measured using the SF-36 and Hospital Anxiety and Depression Scale questionnaires. A total of 724 melanoma survivors and 660 controls participated. Most melanoma survivors had stage I disease (85.6%); mean time from diagnosis was 9.6 ± 1.0 years. Comparisons of QOL measures between melanoma survivors and controls were conducted using regression models, adjusting for potential confounders.
Melanoma survivors, compared to controls, reported statistically significant but only slightly higher physical functioning and bodily pain QOL subscale scores than controls and otherwise similar QOL as measured by the remaining six SF-36 subscale scores. Prevalence of anxiety (18.1% vs. 19.3%, adjusted OR = 1.00 (0.74, 1.36); p = 1.00) and depression (7.2% vs. 9.8%, adjusted OR = 0.74 (0.48, 1.16); p = 1.00) were similar between melanoma survivors and controls.
Long-term early stage melanoma survivors report similar general QOL and mental health compared to population controls. Further research is needed to identify concerns more specific to melanoma.
对于长期黑色素瘤幸存者面临的具体问题了解甚少。本研究的目的是比较长期黑色素瘤幸存者与人群对照者的生活质量（QOL）和心理健康状况。
从先前进行的一项黑色素瘤危险因素病例对照研究中招募参与者进行横断面调查。使用SF - 36和医院焦虑抑郁量表问卷测量一般生活质量和情绪健康状况。共有724名黑色素瘤幸存者和660名对照者参与。大多数黑色素瘤幸存者处于I期疾病（85.6%）；自诊断以来的平均时间为9.6±1.0年。使用回归模型对黑色素瘤幸存者和对照者之间的生活质量测量值进行比较，并对潜在混杂因素进行调整。
与对照者相比，黑色素瘤幸存者报告的身体功能和身体疼痛生活质量子量表得分在统计学上有显著差异，但仅略高于对照者，并且通过其余六个SF - 36子量表得分测量的生活质量在其他方面相似。黑色素瘤幸存者和对照者之间焦虑症（18.1%对19.3%，调整后的OR = 1.00（0.74，1.36）；p = 1.00）和抑郁症（7.2%对9.8%，调整后的OR = 0.74（0.48，1.16）；p = 1.00）的患病率相似。
与人群对照者相比，长期早期黑色素瘤幸存者报告的总体生活质量和心理健康状况相似。需要进一步研究以确定更特定于黑色素瘤的问题。
