Spiller Robin
Nottingham Digestive Diseases Biomedical Research Unit and Nottingham Digestive Diseases Centre, University of Nottingham and Queens Medical Centre, Nottingham, UK.
J Gastroenterol Hepatol. 2017 Mar;32 Suppl 1:36-39. doi: 10.1111/jgh.13694.
Many patients report symptoms come on after eating, and experience with exclusion diets suggests that certainly poorly absorbed but rapidly fermentable carbohydrates may be responsible. While monomeric and short chain carbohydrate polymers exert osmotic forces and trap water in the small bowel with acceleration of transit, the longer polymer polymers such as inulin pass through the small bowel unaltered but are fermented in the colon where they may cause distension and symptoms. Recent developments in magnetic resonance imaging confirm the importance of fructose in stimulating small bowel water secretion and its negation by the presence of glucose. Fructans have no impact on the small intestine but cause colonic distension and symptoms including bloating.
许多患者报告症状在进食后出现，而排除饮食的经验表明，吸收不良但快速发酵的碳水化合物肯定可能是原因所在。虽然单体和短链碳水化合物聚合物会产生渗透力并在小肠中截留水分，加快转运速度，但菊粉等较长的聚合物会完整地通过小肠，却在结肠中发酵，这可能会导致腹胀和出现症状。磁共振成像的最新进展证实了果糖在刺激小肠水分分泌方面的重要性，以及葡萄糖的存在对其的抑制作用。果聚糖对小肠没有影响，但会导致结肠扩张和包括腹胀在内的症状。
