Sprott Centre for Stem Cell Research, Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada; Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada.
Sprott Centre for Stem Cell Research, Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada; Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada.
Cell Stem Cell. 2018 Nov 1;23(5):653-664. doi: 10.1016/j.stem.2018.10.006.
Muscle stem cells, or satellite cells, are required for skeletal muscle maintenance, growth, and repair. Following satellite cell activation, several factors drive asymmetric cell division to generate a stem cell and a proliferative progenitor that forms new muscle. The balance between symmetric self-renewal and asymmetric division significantly impacts the efficiency of regeneration. In this Review, we discuss the relationship of satellite cell heterogeneity and the establishment of polarity to asymmetric division, as well as how these processes are impacted in homeostasis, aging, and disease. We also highlight therapeutic opportunities for targeting satellite cell polarity and self-renewal to stimulate muscle regeneration.
肌卫星细胞是骨骼肌维持、生长和修复所必需的。卫星细胞激活后,有几个因素驱动不对称细胞分裂,产生一个干细胞和一个增殖祖细胞,形成新的肌肉。对称自我更新和不对称分裂之间的平衡显著影响再生效率。在这篇综述中,我们讨论了卫星细胞异质性与极性的建立与不对称分裂的关系,以及这些过程在稳态、衰老和疾病中的影响。我们还强调了靶向卫星细胞极性和自我更新以刺激肌肉再生的治疗机会。