School of Life and Technology and ‡Key Laboratory of Microsystem and Microstructure (Ministry of Education), Harbin Institute of Technology , Harbin 150080, China.
ACS Appl Mater Interfaces. 2017 Mar 22;9(11):9348-9358. doi: 10.1021/acsami.6b15703. Epub 2017 Mar 9.
Image-guided phototherapy is considered to be a prospective technique for cancer treatment because it can provide both oncotherapy and bioimaging, thus achieving an optimized therapeutic efficacy and higher treatment accuracy. Compared to complicated systems with multiple components, using a single material for this multifunctional purpose is preferable. In this work, we strategically fabricated poly(acrylic acid)- (PAA-) coated Cu(OH)PO quantum dots [denoted as Cu(OH)PO@PAA QDs], which exhibit a strong near-infrared photoabsorption ability. As a result, an excellent photothermal conversion ability and the photoactivated formation of reactive oxygen species could be realized upon NIR irradiation, concurrently meeting the basic requirements for photothermal and photodynamic therapies. Moreover, phototherapeutic investigations on both cervical cancer cells in vitro and solid tumors of an in vivo mice model illustrated the effective antitumor effects of Cu(OH)PO@PAA upon 1064-nm laser irradiation, with no detectable lesions in major organs during treatment. Meanwhile, Cu(OH)PO@PAA is also an exogenous contrast for photoacoustic tomography (PAT) imaging to depict tumors under NIR irradiation. In brief, the Cu(OH)PO@PAA QDs prepared in this work are expected to serve as a multifunctional theranostic platform.
基于图像的光疗被认为是一种有前景的癌症治疗技术，因为它可以提供肿瘤治疗和生物成像，从而实现优化的治疗效果和更高的治疗准确性。与具有多个组件的复杂系统相比，使用单一材料来实现这种多功能目的是更可取的。在这项工作中，我们策略性地制备了聚（丙烯酸）（PAA）包覆的 Cu（OH）PO 量子点[表示为 Cu（OH）PO@PAA QDs]，其表现出强的近红外光吸收能力。因此，在近红外光照射下可以实现优异的光热转换能力和光激活活性氧物质的形成，同时满足光热和光动力治疗的基本要求。此外，体外宫颈癌细胞和体内小鼠模型的固瘤的光疗研究表明，Cu（OH）PO@PAA 在 1064nm 激光照射下具有有效的抗肿瘤作用，在治疗过程中主要器官没有可检测到的损伤。同时，Cu（OH）PO@PAA 也是光声断层扫描（PAT）成像的外源性对比剂，可在近红外光照射下描绘肿瘤。总之，本工作中制备的 Cu（OH）PO@PAA QDs 有望作为一种多功能治疗平台。
