Oral Pathology Laboratory and Stomatology, Dentistry Department, Pontifícia Universidade Católica de Minas Gerais, Dom José Gaspar Avenida, 500, 30535-901 Belo Horizonte, MG, Brazil.
Evid Based Complement Alternat Med. 2013;2013:947980. doi: 10.1155/2013/947980. Epub 2013 May 2.
Aim. To evaluate the efficacy of Brazilian green propolis in comparison to miconazole gel in the treatment of Candida-associated denture stomatitis. Methods. Forty-five denture stomatitis patients, with palatal mucosa erythema levels classified according to Newtons's criteria and with positive culture to Candida spp., were randomly divided into three treatment groups: 15 received miconazole gel 2%, 15 received propolis gel 2,5%, and 15 received propolis 24% for mouthwash. After four daily use lasting two weeks, they were reexamined for the denture stomatitis degree and for a second culture of Candida. The Wilcoxon's test was applied to compare the results of clinical classification of the denture stomatitis and the Candida spp. colonies numbers, before and after each treatment. The Kruskall-Wallis's test was used to compare efficacy among the three treatment groups. Results. There were a significant reduction or complete remission of denture stomatitis (P < 0.05) and a significant decrease of Candida colonies for the three groups (P < 0.05). There was no difference in the efficacy among the treatment groups (P > 0.05). Conclusion. Brazilian green propolis has a similar effect as miconazole in the treatment of Candida-associated denture stomatitis being an alternative in the therapeutics of this condition.
目的。评估巴西绿蜂胶与咪康唑凝胶治疗念珠菌相关性义齿性口炎的疗效。方法。45 例腭黏膜红斑按牛顿标准分类，并经念珠菌阳性培养的义齿性口炎患者，随机分为三组治疗：15 例接受咪康唑凝胶 2%，15 例接受蜂胶凝胶 2.5%，15 例接受蜂胶 24%漱口液。连续四天，每天使用两次，持续两周后，重新检查义齿性口炎程度和第二次念珠菌培养。Wilcoxon 检验用于比较三种治疗方法前后义齿性口炎临床分类和念珠菌属菌落数的结果。Kruskal-Wallis 检验用于比较三组之间的疗效。结果。三组患者的义齿性口炎均有显著减轻或完全缓解（P<0.05），念珠菌菌落数也显著减少（P<0.05）。三组之间的疗效无差异（P>0.05）。结论。巴西绿蜂胶与咪康唑凝胶治疗念珠菌相关性义齿性口炎的疗效相似，是该疾病治疗的一种替代方法。
