Chiti M C, Dolmans M M, Donnez J, Amorim C A
Pôle de Recherche en Gynécologie, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Avenue Mounier 52, bte. B1.52.02, 1200, Brussels, Belgium.
Gynecology Department, Cliniques Universitaires Saint-Luc, 1200, Brussels, Belgium.
Ann Biomed Eng. 2017 Jul;45(7):1650-1663. doi: 10.1007/s10439-017-1817-5. Epub 2017 Mar 7.
In recent years, reproductive medicine has made good use of tissue engineering and regenerative medicine techniques to develop alternatives to restore fertility in cancer patients. For young female cancer patients who cannot undergo any of the currently applied strategies due to the possible presence of malignant cells in their ovaries, the challenge is creating an in vitro or in vivo artificial ovary using carefully selected biomaterials. Thanks to its numerous qualities, fibrin has been widely used as a scaffold material for fertility preservation applications. The goal of this review is to examine and discuss the applications and advantages of this biopolymer for fertility restoration in cancer patients, and consider the main results achieved so far.
近年来，生殖医学充分利用组织工程和再生医学技术，开发恢复癌症患者生育能力的替代方法。对于因卵巢中可能存在恶性细胞而无法采用当前任何应用策略的年轻女性癌症患者而言，挑战在于使用精心挑选的生物材料创建体外或体内人工卵巢。由于具有多种特性，纤维蛋白已被广泛用作生育力保存应用的支架材料。本综述的目的是研究和讨论这种生物聚合物在癌症患者生育力恢复方面的应用和优势，并考量迄今取得的主要成果。
