Yamashiroya H M, Ghosh L, Yang R, Robertson A L
Department of Pathology, College of Medicine, University of Illinois, Chicago 60680.
Am J Pathol. 1988 Jan;130(1):71-9.
The presence of herpes simplex virus (HSV) and cytomegalovirus (CMV) nucleic acid and/or antigen was demonstrated in the coronary arteries and thoracic aortas of young trauma victims by the in situ DNA hybridization and ABC immunoperoxidase methods, respectively. Epstein-Barr virus (EBV) nucleic acid and capsid antigen were not detected in the arteries sampled in this study. Of 8 subjects in which virus was detected in the coronary arteries, 6 were positive for HSV and 2 for CMV; of 7 cases positive in the thoracic aorta, 5 were identified as HSV and 2 as CMV. Viral DNA and/or antigen were found in occasional cells in the intact luminal surface and in focal clusters of spindle-shaped or "foamy" cells in the intimal layer. The histologic findings indicate that HSV and CMV are associated with areas showing early or advanced atheromatous changes in the coronary arteries and with lesion-free as well as lesion areas in the thoracic aorta. The virologic findings support the concept that herpes-viruses may potentially play a direct or indirect role in the pathogenesis of human atherosclerosis.
通过原位DNA杂交和ABC免疫过氧化物酶方法，分别在年轻创伤受害者的冠状动脉和胸主动脉中证实了单纯疱疹病毒（HSV）和巨细胞病毒（CMV）核酸及/或抗原的存在。在本研究采集的动脉样本中未检测到爱泼斯坦 - 巴尔病毒（EBV）核酸和衣壳抗原。在冠状动脉中检测到病毒的8名受试者中，6名HSV呈阳性，2名CMV呈阳性；在胸主动脉中呈阳性的7例病例中，5例鉴定为HSV，2例为CMV。在完整管腔表面的偶见细胞以及内膜层中梭形或“泡沫”细胞的局灶性簇中发现了病毒DNA和/或抗原。组织学结果表明，HSV和CMV与冠状动脉中显示早期或晚期动脉粥样硬化改变的区域以及胸主动脉中无病变和有病变的区域相关。病毒学结果支持疱疹病毒可能在人类动脉粥样硬化发病机制中潜在地发挥直接或间接作用这一概念。
