生物响应性经皮贴片
Bioresponsive transcutaneous patches.
作者信息
Yu Jicheng, Zhang Yuqi, Kahkoska Anna R, Gu Zhen
机构信息
Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695, USA; Center for Nanotechnology in Drug Delivery and Division of Pharmacoengineering Molecular Pharmaceutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
出版信息
Curr Opin Biotechnol. 2017 Dec;48:28-32. doi: 10.1016/j.copbio.2017.03.001. Epub 2017 Mar 11.
Transdermal drug delivery systems that utilize transcutaneous patches of arrayed microneedles have attracted increasing interest in medical practice as an alternative method to hypodermic injection. Over the past ten years, research has focused on leveraging physiological signals associated with diseases or skin-specific tissues to create bioresponsive patches that release drug directly in response to an internally-generated stimulus. This review surveys the recent advances in the development and use of bioresponsive transcutaneous patches for on-demand smart and precise drug delivery, exploiting different physiological signals including pH, serum glucose levels, and enzyme activity. The clinical potential of these devices, including challenges and opportunities, is also discussed.
利用排列有微针的经皮贴片的透皮给药系统作为皮下注射的替代方法，在医学实践中已引起越来越多的关注。在过去十年中，研究集中于利用与疾病或皮肤特定组织相关的生理信号来创建生物响应性贴片，使其能够直接响应内部产生的刺激而释放药物。本综述调查了用于按需智能精准给药的生物响应性经皮贴片在开发和应用方面的最新进展，这些贴片利用了包括pH值、血糖水平和酶活性在内的不同生理信号。还讨论了这些设备的临床潜力，包括挑战和机遇。
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