Croughan W S, Behbehani A M
Department of Pathology and Oncology, University of Kansas Medical Center, Kansas City 66103.
J Clin Microbiol. 1988 Feb;26(2):213-5. doi: 10.1128/jcm.26.2.213-215.1988.
A comparative study of the different reactions of herpes simplex virus types 1 and 2 to Lysol, Listerine, bleach, rubbing alcohol, Alcide disinfectant (Alcide Corp., Westport, Conn.), and various pHs, temperatures, and UV light exposures was performed. Both types of stock virus (titers of approximately 10(6) and 10(5.5) for types 1 and 2, respectively) were inactivated by 0.5% Lysol in 5 min; by Listerine (1:1 mixtures) in 5 min; by 2,000 ppm (2,000 microliters/liter) of bleach in 10 min; by rubbing alcohol (1:1 mixtures) at zero time; by Alcide disinfectant (0.2 ml of virus plus 2.0 ml of Alcide) at zero time; by pHs 3, 5, and 11 in 10 min; and by a temperature of 56 degrees C in 30 min. A germicidal lamp (model G30TB; General Electric Co., Schenectady, N.Y.) (30 W) at a distance of 48 cm failed to completely inactivate the two types in 15 min. Type 1 showed slightly more resistance to Listerine and bleach and significantly more resistance to heat; moreover, pH 9 did not affect the infectivity of either type after 10 min.
对1型和2型单纯疱疹病毒对来苏尔、李施德林漱口水、漂白剂、外用酒精、阿尔西德消毒剂（阿尔西德公司，康涅狄格州韦斯特波特）以及不同pH值、温度和紫外线照射的不同反应进行了一项比较研究。两种储备病毒（1型和2型的滴度分别约为10⁶和10⁵·⁵）在5分钟内被0.5%的来苏尔灭活；在5分钟内被李施德林漱口水（1:1混合物）灭活；在10分钟内被2000 ppm（2000微升/升）的漂白剂灭活；在外用酒精（1:1混合物）作用瞬间灭活；在阿尔西德消毒剂（0.2毫升病毒加2.0毫升阿尔西德消毒剂）作用瞬间灭活；在pH值为3、5和11时10分钟内灭活；在56摄氏度下30分钟内灭活。一盏距离为48厘米的杀菌灯（型号G30TB；通用电气公司，纽约州斯克内克塔迪）（30瓦）在15分钟内未能完全灭活这两种病毒。1型病毒对李施德林漱口水和漂白剂的抵抗力稍强，对热的抵抗力明显更强；此外，pH值为9在10分钟后对两种病毒的感染性均无影响。
