Ahmadpour Gholam Reza, Ezatpour Behrouz, Hadighi Ramtin, Oormazdi Hormoz, Akhlaghi Lame, Tabatabaei Fatemeh, Azami Mehdi, Nejad Mozafar Mohammadi, Mahmoudvand Hossein
Department of Medical Parasitology and Mycology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Razi Herbal Medicines Research Center, Department of Medical Parasitology and Mycology, Lorestan University of Medical Sciences, Khorramabad, Iran.
J Parasit Dis. 2017 Mar;41(1):237-242. doi: 10.1007/s12639-016-0784-3. Epub 2016 Jun 2.
Congenital toxoplasmosis can lead to severe damage for the fetus and newborn. Considering that the seroepidemiology of infection in the pregnant women is poorly studied in west of Iran, the main objective of this study was to estimate the seroprevalence and potential risk factors for congenital toxoplasmosis in Delfan, Iran. In this cross-sectional study, the serum samples obtained from pregnant women who were referred to health centers for routine monitoring of the pregnancy. Totally, 264 sera were screened for IgG and IgM anti- antibodies by enzyme linked immunosorbent assay method. All women with IgM anti- positive checked by RT-PCR and confirmed. In addition, structured questionnaires were used to obtain information on risk factors for infection. Anti- IgG and IgM were positive in 66 (25 %) and 15 (5.7 %) respectively. Seropositive subjects were more frequently seen in those with >30 years old compared to younger women (<25 years old) ( < 0.001). No significant relationship was found between the seroprevalence of infection and level of education, and gestational age ( > 0.05), while there was statistical difference between the infection with cat exposure, consumption of raw/undercooked meat, eating raw or uncooked eggs, consumption of unwashed vegetables and drinking unpasteurized milk ( < 0.001). In the present study, it was found that infection was present among pregnant women in west of Iran. Therefore, it is suggested to provide health education for preventing primary infection during pregnancy and subsequently congenital toxoplasmosis in the pregnant women.
先天性弓形虫病可导致胎儿和新生儿严重受损。鉴于伊朗西部孕妇感染的血清流行病学研究较少，本研究的主要目的是估计伊朗德尔凡先天性弓形虫病的血清阳性率及潜在危险因素。在这项横断面研究中，从前往健康中心进行常规孕期监测的孕妇中采集血清样本。总共通过酶联免疫吸附测定法对264份血清进行了抗IgG和抗IgM抗体筛查。所有抗IgM阳性的女性均通过逆转录聚合酶链反应进行检查并确诊。此外，使用结构化问卷获取感染危险因素的信息。抗IgG和抗IgM阳性分别为66例（25%）和15例（5.7%）。与年轻女性（<25岁）相比，30岁以上的女性血清阳性率更高（P<0.001）。未发现感染的血清阳性率与教育程度和孕周之间存在显著关系（P>0.05），而在接触猫、食用生肉/未煮熟的肉、食用生鸡蛋、食用未清洗的蔬菜和饮用未巴氏消毒的牛奶方面，感染情况存在统计学差异（P<0.001）。在本研究中，发现伊朗西部的孕妇中存在感染情况。因此，建议开展健康教育，以预防孕期原发性感染及随后孕妇发生先天性弓形虫病。
