2016年2月，老挝发现携带神经氨酸酶H134N置换的抗流感病毒药物乙型流感病毒。
Antiviral Drug-Resistant Influenza B Viruses Carrying H134N Substitution in Neuraminidase, Laos, February 2016.
作者信息
Baranovich Tatiana, Vongphrachanh Phengta, Ketmayoon Pakapak, Sisouk Thongchanh, Chomlasack Khampheng, Khanthamaly Viengphone, Nguyen Ha Thuy, Mishin Vasiliy P, Marjuki Henju, Barnes John R, Garten Rebecca J, Stevens James, Wentworth David E, Gubareva Larisa V
出版信息
Emerg Infect Dis. 2017 Apr;23(4):686-690. doi: 10.3201/eid2304.161876.
In February 2016, three influenza B/Victoria/2/87 lineage viruses exhibiting 4- to 158-fold reduced inhibition by neuraminidase inhibitors were detected in Laos. These viruses had an H134N substitution in the neuraminidase and replicated efficiently in vitro and in ferrets. Current antiviral drugs may be ineffective in controlling infections caused by viruses harboring this mutation.
2016年2月，在老挝检测到三种B/维多利亚/2/87系流感病毒，它们对神经氨酸酶抑制剂的敏感性降低了4至158倍。这些病毒的神经氨酸酶存在H134N替换，并且在体外和雪貂体内均能有效复制。目前的抗病毒药物可能无法有效控制由携带这种突变的病毒引起的感染。
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