Departments of Cardiology, Heart Valve Clinic, University of Liège Hospital, GIGA Cardiovascular Sciences, CHU Sart Tilman, Liège, Belgium.
Cardiology Department, CHU Tours, France et Université de Tours, Tours, France.
Eur Heart J Cardiovasc Imaging. 2017 Apr 1;18(4):475-483. doi: 10.1093/ehjci/jew284.
To obtain the normal ranges for 3D echocardiography (3DE) measurement of left ventricular (LV) volumes, function, and strain from a large group of healthy volunteers.
A total of 440 (mean age: 45 ± 13 years) out of the 734 healthy subjects enrolled at 22 collaborating institutions of the Normal Reference Ranges for Echocardiography (NORRE) study had good-quality 3DE data sets that have been analysed with a vendor-independent software package allowing homogeneous measurements regardless of the echocardiographic machine used to acquire the data sets. Upper limits of LV end-diastolic and end-systolic volumes were larger in men (97 and 42 mL/m2) than in women (82 and 35 mL/m2; P < 0.0001). Conversely, lower limits of LV ejection fraction were higher in women than in men (51% vs. 50%; P < 0.01). Similarly, all strain components were higher in women than in men. Lower range was -18.6% in men and -19.5% in women for 3D longitudinal strain, -27.0% and -27.6% for 3D circumferential strain, -33.2% and -34.4% for 3D tangential strain and 38.8% and 40.7% for 3D radial strain, respectively. LV volumes decreased with age in both genders (P < 0.0001), whereas LV ejection fraction increased with age only in men. Among 3DE LV strain components, the only one, which did not change with age was longitudinal strain.
The NORRE study provides applicable 3D echocardiographic reference ranges for LV function assessment. Our data highlight the importance of age- and gender-specific reference values for both LV volumes and strain.
从大量健康志愿者中获得三维超声心动图（3DE）测量左心室（LV）容积、功能和应变的正常范围。
在参与正常参考范围超声心动图（NORRE）研究的 22 个合作机构中，共有 734 名健康受试者中的 440 名（平均年龄：45±13 岁）获得了高质量的 3DE 数据集，这些数据集已经使用与供应商无关的软件包进行了分析，允许无论用于获取数据集的超声心动图机器如何，都可以进行同质测量。男性的 LV 舒张末期和收缩末期容积上限（97 和 42mL/m2）大于女性（82 和 35mL/m2；P<0.0001）。相反，女性的 LV 射血分数下限高于男性（51%对 50%；P<0.01）。同样，所有应变分量在女性中均高于男性。3D 纵向应变的男性下限为-18.6%，女性下限为-19.5%，3D 环向应变的男性下限为-27.0%，女性下限为-27.6%，3D 切向应变的男性下限为-33.2%，女性下限为-34.4%，3D 径向应变的男性下限为 38.8%，女性下限为 40.7%。在两性中，LV 容积随年龄而降低（P<0.0001），而 LV 射血分数仅在男性中随年龄增加。在 3DE LV 应变分量中，唯一不变的是纵向应变。
NORRE 研究提供了适用于 LV 功能评估的三维超声心动图参考范围。我们的数据强调了年龄和性别特异性参考值对 LV 容积和应变的重要性。
