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针对水生和陆生生物细菌病原体的噬菌体疗法综述

A Review of Phage Therapy against Bacterial Pathogens of Aquatic and Terrestrial Organisms.

作者信息

Doss Janis, Culbertson Kayla, Hahn Delilah, Camacho Joanna, Barekzi Nazir

机构信息

Old Dominion University, Department of Biological Sciences, 5115 Hampton Blvd, Norfolk, VA 23529, USA.

出版信息

Viruses. 2017 Mar 18;9(3):50. doi: 10.3390/v9030050.

Abstract

Since the discovery of bacteriophage in the early 1900s, there have been numerous attempts to exploit their innate ability to kill bacteria. The purpose of this report is to review current findings and new developments in phage therapy with an emphasis on bacterial diseases of marine organisms, humans, and plants. The body of evidence includes data from studies investigating bacteriophage in marine and land environments as modern antimicrobial agents against harmful bacteria. The goal of this paper is to present an overview of the topic of phage therapy, the use of phage-derived protein therapy, and the hosts that bacteriophage are currently being used against, with an emphasis on the uses of bacteriophage against marine, human, animal and plant pathogens.

摘要

自20世纪初发现噬菌体以来,人们多次尝试利用其杀灭细菌的天然能力。本报告旨在回顾噬菌体疗法的当前研究结果和新进展,重点关注海洋生物、人类和植物的细菌性疾病。证据主体包括在海洋和陆地环境中研究噬菌体作为对抗有害细菌的现代抗菌剂的数据。本文的目的是概述噬菌体疗法这一主题、噬菌体衍生蛋白疗法的应用以及目前噬菌体所针对的宿主,重点是噬菌体在对抗海洋、人类、动物和植物病原体方面的应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c887/5371805/1805d003f7b2/viruses-09-00050-g001.jpg

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