López-López Arantxa, Camelo-Castillo Anny, Ferrer María D, Simon-Soro Áurea, Mira Alex
Department of Health and Genomics, Center for Advanced Research in Public Health, FISABIO Foundation Valencia, Spain.
Front Microbiol. 2017 Mar 10;8:379. doi: 10.3389/fmicb.2017.00379. eCollection 2017.
Oral diseases, including dental caries and periodontitis, are among the most prevalent diseases worldwide and develop as a consequence of a microbial dysbiosis. Several bacterial strains are being tested as potential oral health-promoting organisms, but usually they are species isolated from niches other than the site where they must exert its probiotic action, typically from fecal samples. We hypothesize that oral inhabitants associated to health conditions will be more effective than traditional, gut-associated probiotic species in key aspects such as colonization of the oral site where disease takes place or the possession of oral health promoting functions, as well as more practical issues like safety and toxicity, and establishing proper doses for administration. As an example of these , we describe the case of , a new streptococcal species isolated from dental plaque of caries-free individuals. We have detected it in 98% of dental plaque samples from healthy individuals and, as expected, it does not produce any toxic secondary metabolite and does not survive a simulated stomach digestion, preventing potential secondary effects. Besides, this species has a double probiotic action, as it inhibits the growth of major oral pathogens through the production of bacteriocins, and also buffers acidic pH (the primary cause of dental caries) through an arginolytic pathway. We propose the use of as a promising probiotic against tooth decay.
口腔疾病，包括龋齿和牙周炎，是全球最普遍的疾病之一，是微生物群落失调的结果。几种细菌菌株正在作为潜在的口腔健康促进微生物进行测试，但通常它们是从与其必须发挥益生菌作用的部位不同的生态位分离出来的物种，通常是从粪便样本中分离出来的。我们假设，与健康状况相关的口腔微生物在关键方面将比传统的、与肠道相关的益生菌物种更有效，例如在疾病发生部位的口腔定植、拥有促进口腔健康的功能，以及在安全性和毒性等更实际的问题上，以及确定合适的给药剂量。作为这些例子之一，我们描述了从无龋个体的牙菌斑中分离出的一种新的链球菌物种的情况。我们在98%的健康个体牙菌斑样本中检测到了它，正如预期的那样，它不会产生任何有毒的次生代谢物，并且在模拟胃消化中无法存活，从而防止了潜在的次生影响。此外，该物种具有双重益生菌作用，因为它通过产生细菌素抑制主要口腔病原体的生长，并且还通过精氨酸分解途径缓冲酸性pH值（龋齿的主要原因）。我们建议将其用作预防龋齿的有前景的益生菌。
