Veselinovic Mirjana, Vasiljevic Dragan, Vucic Vesna, Arsic Aleksandra, Petrovic Snjezana, Tomic-Lucic Aleksandra, Savic Maja, Zivanovic Sandra, Stojic Vladislava, Jakovljevic Vladimir
Department of Internal medicine, Faculty of Medical Sciences, University of Kragujevac, Kragujevac 34000, Serbia.
Department of Hygiene, Institute for Public Health, Faculty of Medical Sciences, University of Kragujevac, Kragujevac 34000, Serbia.
Nutrients. 2017 Mar 25;9(4):325. doi: 10.3390/nu9040325.
(1) Background: Marine -3 polyunsaturated fatty acids (PUFA) and ɤ-linolenic acid (GLA) are well-known anti-inflammatory agents that may help in the treatment of inflammatory disorders. Their effects were examined in patients with rheumatoid arthritis; (2) Methods: Sixty patients with active rheumatoid arthritis were involved in a prospective, randomized trial of a 12 week supplementation with fish oil (group I), fish oil with primrose evening oil (group II), or with no supplementation (group III). Clinical and laboratory evaluations were done at the beginning and at the end of the study; (3) Results: The Disease Activity Score 28 (DAS 28 score), number of tender joints and visual analogue scale (VAS) score decreased notably after supplementation in groups I and II ( < 0.001). In plasma phospholipids the -6/-3 fatty acids ratio declined from 15.47 ± 5.51 to 10.62 ± 5.07 ( = 0.005), and from 18.15 ± 5.04 to 13.50 ± 4.81 ( = 0.005) in groups I and II respectively. The combination of -3 PUFA and GLA (group II) increased ɤ-linolenic acid (0.00 ± 0.00 to 0.13 ± 0.11, < 0.001), which was undetectable in all groups before the treatments; (4) Conclusion: Daily supplementation with -3 fatty acids alone or in combination with GLA exerted significant clinical benefits and certain changes in disease activity.
（1）背景：海洋ω-3多不饱和脂肪酸（PUFA）和γ-亚麻酸（GLA）是著名的抗炎剂，可能有助于治疗炎症性疾病。对类风湿性关节炎患者的疗效进行了研究；（2）方法：60例活动性类风湿性关节炎患者参与了一项前瞻性随机试验，分别补充鱼油（第一组）、鱼油与月见草油（第二组）或不补充（第三组），为期12周。在研究开始和结束时进行临床和实验室评估；（3）结果：第一组和第二组补充后，疾病活动评分28（DAS 28评分）、压痛关节数和视觉模拟量表（VAS）评分显著降低（P<0.001）。第一组和第二组血浆磷脂中ω-6/ω-3脂肪酸比值分别从15.47±5.51降至10.62±5.07（P = 0.005）和从18.15±5.04降至13.50±4.81（P = 0.005）。ω-3多不饱和脂肪酸与γ-亚麻酸联合使用（第二组）使γ-亚麻酸增加（从0.00±0.00增至0.13±0.11，P<0.001），治疗前所有组均未检测到；（4）结论：每日单独补充ω-3脂肪酸或与γ-亚麻酸联合补充具有显著的临床益处，并使疾病活动发生一定变化。
