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用于生物成像的上转换近红外光子

Upconverting NIR Photons for Bioimaging.

作者信息

Li Zhanjun, Zhang Yuanwei, La Hieu, Zhu Richard, El-Banna Ghida, Wei Yuzou, Han Gang

机构信息

Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA.

出版信息

Nanomaterials (Basel). 2015 Dec 4;5(4):2148-2168. doi: 10.3390/nano5042148.

DOI:10.3390/nano5042148
PMID:28347113
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5304770/
Abstract

Lanthanide-doped upconverting nanoparticles (UCNPs) possess uniqueanti-Stokes optical properties, in which low energy near-infrared (NIR) photons can beconverted into high energy UV, visible, shorter NIR emission via multiphoton upconversionprocesses. Due to the rapid development of synthesis chemistry, lanthanide-doped UCNPscan be fabricated with narrow distribution and tunable multi-color optical properties. Theseunique attributes grant them unique NIR-driven imaging/drug delivery/therapeuticapplications, especially in the cases of deep tissue environments. In this brief review, weintroduce both the basic concepts of and recent progress with UCNPs in material engineeringand theranostic applications in imaging, molecular delivery, and tumor therapeutics. The aimof this brief review is to address the most typical progress in basic mechanism, materialdesign as bioimaging tools.

摘要

镧系元素掺杂的上转换纳米粒子（UCNPs）具有独特的反斯托克斯光学特性，其中低能量的近红外（NIR）光子可以通过多光子上转换过程转换为高能量的紫外线、可见光、更短波长的近红外发射光。由于合成化学的快速发展，镧系元素掺杂的UCNPs可以被制备成具有窄分布和可调谐多色光学特性的材料。这些独特的属性赋予了它们独特的近红外驱动成像/药物递送/治疗应用，特别是在深部组织环境中。在这篇简短的综述中，我们介绍了UCNPs在材料工程以及成像、分子递送和肿瘤治疗的诊疗应用方面的基本概念和最新进展。这篇简短综述的目的是阐述在基本机制、作为生物成像工具的材料设计方面最典型的进展。

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