用基因组流行病学宣布结核病疫情结束。
Declaring a tuberculosis outbreak over with genomic epidemiology.
机构信息
1CoMPLEX, University College London Research Department of Infection and Population Health, University College London, London, UK.
2Department of Infectious Disease Epidemiology, Imperial College London, London, UK.
出版信息
Microb Genom. 2016 May 31;2(5):e000060. doi: 10.1099/mgen.0.000060. eCollection 2016 May.
We report an updated method for inferring the time at which an infectious disease was transmitted between persons from a time-labelled pathogen genome phylogeny. We applied the method to 48 genomes as part of a real-time public health outbreak investigation, demonstrating that although active tuberculosis (TB) cases were diagnosed through 2013, no transmission events took place beyond mid-2012. Subsequent cases were the result of progression from latent TB infection to active disease, and not recent transmission. This evolutionary genomic approach was used to declare the outbreak over in January 2015.
我们报告了一种从带时间标记的病原体基因组系统发育推断人与人之间传染病传播时间的更新方法。我们将该方法应用于 48 个基因组，作为实时公共卫生暴发调查的一部分，结果表明，尽管活动性肺结核（TB）病例在 2013 年被诊断，但在 2012 年年中之后没有发生传播事件。随后的病例是潜伏性结核感染向活动性疾病发展的结果，而不是最近的传播。这种进化基因组方法被用于在 2015 年 1 月宣布疫情结束。
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