UFT - Centre for Environmental Research and Technology, University of Bremen, Leobener Straße, D-28359 Bremen, Germany.
Department of Colloid and Lipid Science, Faculty of Chemistry, Gdańsk University of Technology, ul. Narutowicza 11/12, 80-233 Gdańsk, Poland.
J Hazard Mater. 2017 Jul 5;333:154-161. doi: 10.1016/j.jhazmat.2017.03.030. Epub 2017 Mar 16.
Hypoglycaemic pharmaceuticals are recently more and more frequently detected in the environment. In our previous study, we have shown that even though many of them undergo significant primary degradation some are transformed to stable products or undergo such transformation that a large part of the structure is still preserved. One of the main routes of elimination from wastewaters or surface waters is biodegradation and a lack thereof leads to accumulation in the environment. Within this work we tested the ultimate biodegradability of six oral antidiabetics: metformin and its main metabolite guanylurea, acarbose, glibenclamide, gliclazide, glimepiride and repaglinide. We also compared the experimental results obtained in this and accompanying work with models designed to predict biodegradability and showed that these models are only moderately successful. Additionally, we examined these compounds in acute Daphnia magna test to check if they might pose an ecotoxicological threat. Combining the results of biodegradability and toxicity tests allows a preliminary assessment of their potential environmental impact.
低血糖药物最近在环境中越来越频繁地被检测到。在我们之前的研究中，我们已经表明，尽管其中许多药物会经历显著的初级降解，但有些药物会转化为稳定的产物，或者经历这样的转化，以至于大部分结构仍然保留。从废水或地表水中消除的主要途径之一是生物降解，如果缺乏生物降解，就会导致在环境中的积累。在这项工作中，我们测试了六种口服抗糖尿病药物的最终生物降解性：二甲双胍及其主要代谢物胍基脲、阿卡波糖、格列本脲、格列齐特、格列美脲和瑞格列奈。我们还将本工作和伴随工作中获得的实验结果与旨在预测生物降解性的模型进行了比较，结果表明这些模型只是中等成功。此外，我们还在急性大型蚤试验中检查了这些化合物，以检查它们是否可能构成生态毒理学威胁。将生物降解性和毒性测试的结果结合起来，可以对它们的潜在环境影响进行初步评估。
