饮酒后脸红与癌症风险：一项荟萃分析。
Facial flushing after alcohol consumption and the risk of cancer: A meta-analysis.
作者信息
Zhang Jing, Zhang Sunfu, Song Yanlin, Ma Guangzhi, Meng Yu, Ye Zengpanpan, Ma Xuelei, Liu Ming
机构信息
Department of Medical Oncology, West China Hospital of Sichuan University, The First People's Hospital of Yibin West China Medical School of Sichuan University, Sichuan, PR China.
出版信息
Medicine (Baltimore). 2017 Mar;96(13):e6506. doi: 10.1097/MD.0000000000006506.
BACKGROUND
The association between facial flushing after alcohol consumption and the risk of cancer remains controversial. The aim of this study was to evaluate the relation between facial flushing and cancer risk.
METHODS
PubMed, EMBASE, and Cochrane Library were searched for relevant literature. The patients' baseline characteristics and estimated risks were extracted. Odds ratios (ORs) with 95% confidence intervals (CIs) were pooled to estimate the risk of facial flushing in cancer, and subgroup analysis was performed.
RESULTS
Ten studies with 89,376 participants from East Asia were included. The pooled OR of facial flushing in all cancers was 1.43 (95% CI, 1.08-1.91), with the pooled ORs of 1.94 (95% CI, 1.33-2.83) and 0.95 (95% CI, 0.80-1.12) in men and women, respectively. The pooled ORs were also estimated in different cancer types.
CONCLUSION
Our results showed that facial flushing response to alcohol was associated with higher cancer risk in men in East Asia, especially in esophageal squamous cell carcinoma, yet facial flushing was not significantly associated with cancer risk among women.
背景
饮酒后脸红与癌症风险之间的关联仍存在争议。本研究旨在评估脸红与癌症风险之间的关系。
方法
检索PubMed、EMBASE和Cochrane图书馆中的相关文献。提取患者的基线特征和估计风险。汇总具有95%置信区间（CI）的比值比（OR），以估计癌症患者脸红的风险，并进行亚组分析。
结果
纳入了10项来自东亚的研究，共89376名参与者。所有癌症患者脸红的汇总OR为1.43（95%CI，1.08 - 1.91），男性和女性的汇总OR分别为1.94（95%CI，1.33 - 2.83）和0.95（95%CI，0.80 - 1.12）。还对不同癌症类型的汇总OR进行了估计。
结论
我们的结果表明，在东亚男性中，饮酒后的脸红反应与较高的癌症风险相关，尤其是食管鳞状细胞癌，但脸红与女性的癌症风险无显著关联。
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