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维生素D缺乏会导致高血压吗?

Does Vitamin D Deficiency Lead to Hypertension?

作者信息

Mehta Varshil, Agarwal Shivika

机构信息

Department of Cardiology, Mount Sinai Hospital, New York, USA.

Department of Forensic Medicine, ESIC Medical College, Faridabad, India.

出版信息

Cureus. 2017 Feb 17;9(2):e1038. doi: 10.7759/cureus.1038.

DOI:10.7759/cureus.1038
PMID:28357170
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5356990/
Abstract

Hypertension (HTN) or high blood pressure is one of the most chronic and deadliest disorders in the world. There are many risk factors responsible for HTN which include age, race, using tobacco, high salt intake, etc. One of the risk factors we would like to highlight is low vitamin D levels. While there is strong evidence that Vitamin D plays an important role in maintaining bone and muscle health, there has been recent debate regarding its role in hypertension. However, there are many studies that have shown an indirect relation between 25-hydroxyvitamin D serum level and blood pressure. However, we suggest that more studies, especially randomised trials, should be conducted.

摘要

高血压(HTN)或高血压是世界上最常见的慢性和致命疾病之一。导致高血压的风险因素有很多,包括年龄、种族、吸烟、高盐摄入等。我们想强调的一个风险因素是维生素 D 水平低。虽然有强有力的证据表明维生素 D 在维持骨骼和肌肉健康方面发挥着重要作用,但最近关于其在高血压中的作用存在争议。然而,许多研究表明 25 - 羟基维生素 D 血清水平与血压之间存在间接关系。不过,我们建议应该进行更多的研究,尤其是随机试验。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b6e/5356990/50b02d7e6381/cureus-0009-00000001038-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b6e/5356990/50b02d7e6381/cureus-0009-00000001038-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b6e/5356990/50b02d7e6381/cureus-0009-00000001038-i01.jpg

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本文引用的文献

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Low vitamin D and hypertension: a causal association?低维生素D与高血压:存在因果关联吗?
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2
Association of vitamin D status with arterial blood pressure and hypertension risk: a mendelian randomisation study.维生素 D 状态与动脉血压和高血压风险的关联:一项孟德尔随机研究。
Lancet Diabetes Endocrinol. 2014 Sep;2(9):719-29. doi: 10.1016/S2213-8587(14)70113-5. Epub 2014 Jun 25.
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Vitamin D metabolism, mechanism of action, and clinical applications.
维生素 D 缺乏在心血管和脑血管疾病发病机制中的作用。
Nutrients. 2023 Jan 9;15(2):334. doi: 10.3390/nu15020334.
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Age-dependent changes in fat- and water-soluble vitamins-National Health and Nutrition Examination Surveys study.脂溶性和水溶性维生素随年龄的变化——美国国家健康与营养检查调查研究
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Prevalence of Vitamin D Deficiency Between Type 2 Diabetes Mellitus Patients and Non-Diabetics in the Arab Gulf.阿拉伯海湾地区2型糖尿病患者与非糖尿病患者中维生素D缺乏症的患病率
Diabetes Metab Syndr Obes. 2022 Feb 28;15:647-657. doi: 10.2147/DMSO.S350626. eCollection 2022.
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Ann Pediatr Endocrinol Metab. 2022 Jun;27(2):113-120. doi: 10.6065/apem.2142158.079. Epub 2021 Nov 15.
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Vitamin D Supplementation and Blood Pressure in Children and Adolescents: A Systematic Review and Meta-Analysis.维生素 D 补充与儿童和青少年的血压:系统评价和荟萃分析。
Nutrients. 2020 Apr 22;12(4):1163. doi: 10.3390/nu12041163.
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BMC Neurol. 2020 Mar 31;20(1):116. doi: 10.1186/s12883-020-01686-4.
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