Robinson Jason D, Kypriotakis George, Karam-Hage Maher, Green Charles E, Hatsukami Dorothy K, Cinciripini Paul M, Donny Eric C
Department of Behavioral Science, University of Texas MD Anderson Cancer Center, Houston, TX.
Center for Clinical Research and Evidence-Based Medicine, Department of Pediatrics, UTHealth, Houston, TX.
Nicotine Tob Res. 2017 Sep 1;19(9):1080-1086. doi: 10.1093/ntr/ntx068.
Research suggests a strong association between negative affect (NA) and smoking. However, little is known about the association between NA and smoking among individuals who switch to reduced-nicotine cigarettes. The goal of this study was to examine the extent to which cigarette nicotine content moderates the relationship between NA and smoking over time.
Seven hundred and seventeen participants, 237 in the normal nicotine content (NNC; 15.8 mg/g and usual brand) cigarette group and 480 in the very low nicotine content (VLNC; 2.4 mg/g nicotine or less) cigarette group, participated in a randomized trial that examined the effects of cigarette nicotine content on smoking behavior over 6 weeks. We used parallel process latent growth curve modeling to estimate the relationship between changes in NA and changes in the numbers of cigarettes smoked per day (CPD), from baseline to 6 weeks, as a function of cigarette nicotine content.
The relationship between NA and investigational CPD reduced over time for those in the VLNC group, but not for those in the NNC group. There was no significant relationship between change in PA and CPD over time for either cigarette group.
Smoking VLNC cigarettes disrupts the relationship between smoking and negative affect, which may help reduce nicotine dependence.
This study suggests that the association between NA and smoking behavior is reduced over time among those that smoked reduced-nicotine content cigarettes. This provides additional evidence that smoking reduced-nicotine content cigarettes may help reduce nicotine dependence.
研究表明消极情绪（NA）与吸烟之间存在紧密联系。然而，对于改用低尼古丁香烟的人群中NA与吸烟之间的关联却知之甚少。本研究的目的是考察香烟尼古丁含量在多大程度上随时间调节NA与吸烟之间的关系。
717名参与者，其中237人在正常尼古丁含量（NNC；15.8毫克/克及常规品牌）香烟组，480人在极低尼古丁含量（VLNC；2.4毫克/克尼古丁或更低）香烟组，参与了一项随机试验，该试验考察了香烟尼古丁含量在6周内对吸烟行为的影响。我们使用平行过程潜在增长曲线模型来估计从基线到6周期间NA变化与每日吸烟量（CPD）变化之间的关系，作为香烟尼古丁含量的函数。
VLNC组中，NA与试验CPD之间的关系随时间减弱，但NNC组中并非如此。两个香烟组中，随时间PA变化与CPD之间均无显著关系。
吸食VLNC香烟会破坏吸烟与消极情绪之间的关系，这可能有助于降低尼古丁依赖。
本研究表明，随着时间推移，吸食低尼古丁含量香烟的人群中NA与吸烟行为之间的关联会减弱。这提供了额外证据，表明吸食低尼古丁含量香烟可能有助于降低尼古丁依赖。
