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Nanomedicine: Evolution of the nanoparticle corona.

作者信息

Hadjidemetriou Marilena, Kostarelos Kostas

机构信息

Nanomedicine Lab, Faculty of Biology, Medicine &Health and the National Graphene Institute, AV Hill Building, The University of Manchester, Manchester M13 9PT, UK.

出版信息

Nat Nanotechnol. 2017 Apr 6;12(4):288-290. doi: 10.1038/nnano.2017.61.

DOI:10.1038/nnano.2017.61
PMID:28383044
Abstract
摘要

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Time-evolution of in vivo protein corona onto blood-circulating PEGylated liposomal doxorubicin (DOXIL) nanoparticles.体内蛋白质冠在血液循环中的聚乙二醇化脂质体阿霉素(DOXIL)纳米颗粒上的时间演变。
Nanoscale. 2016 Apr 7;8(13):6948-57. doi: 10.1039/c5nr09158f. Epub 2016 Mar 10.
2
In Vivo Biomolecule Corona around Blood-Circulating, Clinically Used and Antibody-Targeted Lipid Bilayer Nanoscale Vesicles.在血液循环、临床应用和抗体靶向脂质双层纳米囊泡周围的活体生物分子冠。
ACS Nano. 2015 Aug 25;9(8):8142-56. doi: 10.1021/acsnano.5b03300. Epub 2015 Jul 10.
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The nanoparticle biomolecule corona: lessons learned - challenge accepted?
Nat Nanotechnol. 2025 Jun 3. doi: 10.1038/s41565-025-01944-x.
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The Protein Corona Paradox: Challenges in Achieving True Biomimetics in Nanomedicines.蛋白质冠层悖论:纳米药物中实现真正仿生学面临的挑战。
Biomimetics (Basel). 2025 Apr 29;10(5):276. doi: 10.3390/biomimetics10050276.
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Surface Charge Overrides Protein Corona Formation in Determining the Cytotoxicity, Cellular Uptake, and Biodistribution of Silver Nanoparticles.在决定银纳米颗粒的细胞毒性、细胞摄取和生物分布方面,表面电荷超越蛋白质冠形成的影响。
ACS Appl Bio Mater. 2025 Jun 16;8(6):5032-5043. doi: 10.1021/acsabm.5c00392. Epub 2025 May 21.
6
In situ protein corona-camouflaged supramolecular assemblies remodel thrombotic microenvironment for improved arterial homeostasis.原位蛋白质冠层伪装的超分子组装体重塑血栓形成微环境以改善动脉内稳态。
Sci Adv. 2025 May 2;11(18):eadu6676. doi: 10.1126/sciadv.adu6676.
7
Biotransformation and biological fate of magnetic iron oxide nanoparticles for biomedical research and clinical applications.用于生物医学研究和临床应用的磁性氧化铁纳米颗粒的生物转化与生物学命运
Nanoscale Adv. 2025 Mar 24;7(10):2818-2886. doi: 10.1039/d5na00195a. eCollection 2025 May 13.
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Plasma-to-tumour tissue integrated proteomics using nano-omics for biomarker discovery in glioblastoma.使用纳米组学进行血浆与肿瘤组织整合蛋白质组学研究以发现胶质母细胞瘤的生物标志物
Nat Commun. 2025 Apr 10;16(1):3412. doi: 10.1038/s41467-025-58252-0.
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Nanocarrier imaging at single-cell resolution across entire mouse bodies with deep learning.利用深度学习在单细胞分辨率下对整个小鼠身体进行纳米载体成像。
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纳米颗粒生物分子冠:经验教训——迎难而上?
Chem Soc Rev. 2015 Oct 7;44(17):6094-121. doi: 10.1039/c5cs00217f. Epub 2015 Jun 11.
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Exploiting the novel properties of protein coronas: emerging applications in nanomedicine.利用蛋白质冠的新特性:在纳米医学中的新兴应用。
Nanomedicine (Lond). 2015 May;10(10):1663-74. doi: 10.2217/nnm.15.6.
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Corona-directed nucleic acid delivery into hepatic stellate cells for liver fibrosis therapy.用于肝纤维化治疗的肝星状细胞内冠状靶向核酸递送
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Rapid formation of plasma protein corona critically affects nanoparticle pathophysiology.血浆蛋白冠的快速形成严重影响纳米颗粒的病理生理学。
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Transferrin-functionalized nanoparticles lose their targeting capabilities when a biomolecule corona adsorbs on the surface.当生物分子冠吸附在表面时,转铁蛋白功能化的纳米颗粒会失去其靶向能力。
Nat Nanotechnol. 2013 Feb;8(2):137-43. doi: 10.1038/nnano.2012.237. Epub 2013 Jan 20.
9
Protein corona-mediated mitigation of cytotoxicity of graphene oxide.蛋白冠介导的氧化石墨烯细胞毒性缓解。
ACS Nano. 2011 May 24;5(5):3693-700. doi: 10.1021/nn200021j. Epub 2011 Apr 21.
10
Time evolution of the nanoparticle protein corona.纳米颗粒蛋白冠的时间演化。
ACS Nano. 2010 Jul 27;4(7):3623-32. doi: 10.1021/nn901372t.