Vaudin M, Wolstenholme A J, Tsiquaye K N, Zuckerman A J, Harrison T J
Department of Medical Microbiology, London School of Hygiene and Tropical Medicine, U.K.
J Gen Virol. 1988 Jun;69 ( Pt 6):1383-9. doi: 10.1099/0022-1317-69-6-1383.
The complete nucleotide sequence of a strain of hepatitis B virus, originally isolated from a naturally infected chimpanzee, has been determined. Interesting features of the sequence include the presence of an in-phase stop codon in the 'pre-core' region of the core antigen open reading frame. The sequence shows approximately 10% nucleotide divergence from all of the other hepatitis B virus sequences previously published and the possibility that this divergence is the result of passage through chimpanzees is discussed.
已测定了一株最初从自然感染的黑猩猩中分离出的乙型肝炎病毒的完整核苷酸序列。该序列的有趣特征包括在核心抗原开放阅读框的“前核心”区域存在一个同相位终止密码子。该序列与先前发表的所有其他乙型肝炎病毒序列显示出约10%的核苷酸差异，并讨论了这种差异是通过黑猩猩传代导致的可能性。
