Zhang Mengyan, Xin Ruolei, Chang Wenhui
1 Department of AIDS Prevention and Control, Shaanxi Provincial Center for Disease Prevention and Control , Xi'an, China .
2 Institute of STD/AIDS Prevention and Control, Beijing Center for Disease Prevention and Control , Beijing, China .
AIDS Res Hum Retroviruses. 2018 May;34(5):467-470. doi: 10.1089/AID.2018.0003. Epub 2018 Apr 2.
Many new circulating recombinant forms (CRFs) and unique recombinant forms (URFs) of HIV-1 have been found in men who have sex with men (MSM) in recent years, in China. In this study, a unique HIV-1 recombinant genome (SN153) was characterized from an HIV-positive male infected through homosexual behavior in Shaanxi, China. The mosaic pattern had a complex intersubtype recombinant structure with six breakpoints, with three subtype C segments inserted into subtype B backbone. And three similar breakpoints with CRF07_BC were observed in the pol gene. The identification of the new URF suggested the genetic complexity of the HIV epidemic among MSM in Shaanxi province and the urgent need for epidemiological surveillance and their origin of the new recombination forms.
近年来，在中国，男男性行为者（MSM）中发现了许多新的HIV-1循环重组型（CRF）和独特重组型（URF）。在本研究中，从中国陕西省一名通过同性恋行为感染HIV的阳性男性中鉴定出一种独特的HIV-1重组基因组（SN153）。该镶嵌模式具有复杂的亚型间重组结构，有六个断点，三个C亚型片段插入到B亚型主干中。并且在pol基因中观察到与CRF07_BC有三个相似的断点。新URF的鉴定表明陕西省MSM中HIV流行的遗传复杂性，以及对流行病学监测及其新重组形式起源的迫切需求。
