Ansari Shamshul, Yamaoka Yoshio
Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, Yufu, Japan.
Department of Medicine-Gastroenterology, Baylor College of Medicine, Houston, TX, USA.
Helicobacter. 2017 Aug;22(4). doi: 10.1111/hel.12386. Epub 2017 Apr 12.
Helicobacter pylori is well adapted to colonize the epithelial surface of the human gastric mucosa and can cause persistent infections. In order to infect the gastric mucosa, it has to survive in the gastric acidic pH. This organism has well developed mechanisms to neutralize the effects of acidic pH.
This review article was designed to summarize the various functional and molecular aspects by which the bacterium can combat and survive the gastric acidic pH in order to establish the persistent infections.
We used the keywords (acid acclimation, gastric acidic environment, H. pylori and survival) in combination or alone for pubmed search of recent scientific literatures. One hundred and forty one papers published between 1989 and 2016 were sorted out. The articles published with only abstracts, other than in English language, case reports and reviews were excluded.
Many literatures describing the role of several factors in acid survival were found. Recently, the role of several other factors has been claimed to participate in acid survival.
In conclusion, this organism has well characterized mechanisms for acid survival.
幽门螺杆菌非常适合在人胃黏膜上皮表面定殖，并可导致持续性感染。为了感染胃黏膜，它必须在胃的酸性pH环境中存活。该菌具有完善的机制来中和酸性pH的影响。
这篇综述文章旨在总结该细菌对抗胃酸性pH并在其中存活以建立持续性感染的各种功能和分子方面。
我们使用关键词（酸适应、胃酸性环境、幽门螺杆菌和存活）单独或组合在PubMed上搜索近期科学文献。筛选出1989年至2016年间发表的141篇论文。排除仅发表摘要、非英文、病例报告和综述类文章。
发现许多文献描述了多种因素在酸存活中的作用。最近，有人声称其他几种因素也参与酸存活。
总之，该菌具有明确的酸存活机制。
