通过聚合酶链反应对比利时旅行者的鼠型斑疹伤寒和恙虫病进行急性期诊断：病例报告
Acute-phase diagnosis of murine and scrub typhus in Belgian travelers by polymerase chain reaction: a case report.
作者信息
Theunissen Caroline, Cnops Lieselotte, Van Esbroeck Marjan, Huits Ralph, Bottieau Emmanuel
机构信息
Institute of Tropical Medicine, Department of Clinical Sciences, Nationale straat 155, 2000, Antwerp, Belgium.
出版信息
BMC Infect Dis. 2017 Apr 13;17(1):273. doi: 10.1186/s12879-017-2385-x.
Abstract
BACKGROUND
Rickettsiosis is a potential life threatening infectious disease in travelers. Clinical recognition is not always straightforward, as typical manifestations such as rash and/or eschar may be absent. Definite diagnosis is based on seroconversion and therefore often delayed until the convalescent phase of disease.
CASE PRESENTATION
In this case report, we describe four patients with severe travel-related rickettsiosis (two patients with murine- and two patients with scrub typhus), in whom acute- phase diagnosis was possible by real-time polymerase chain reaction on serum or blood.
CONCLUSIONS
Despite its limitations, we think that polymerase chain reaction can contribute significantly to the early diagnosis and treatment of rickettsial disease in travelers.
摘要
背景
立克次体病对旅行者来说是一种可能危及生命的传染病。临床识别并不总是那么简单直接，因为可能没有皮疹和/或焦痂等典型表现。确诊基于血清转化，因此往往会延迟到疾病的恢复期。
病例报告
在本病例报告中，我们描述了4例与旅行相关的严重立克次体病患者（2例鼠型斑疹伤寒患者和2例恙虫病患者），通过对血清或血液进行实时聚合酶链反应，在急性期即可确诊。
结论
尽管存在局限性，但我们认为聚合酶链反应可对旅行者立克次体病的早期诊断和治疗做出重大贡献。
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