Miller C C, Ziboh V A
Department of Dermatology, School of Medicine, University of California, Davis 95616.
Biochem Biophys Res Commun. 1988 Aug 15;154(3):967-74. doi: 10.1016/0006-291x(88)90234-3.
There are reports that vegetable oils containing gammalinolenic acid (GLA) may exert beneficial effects on inflammatory skin disorders. To determine whether or not dietary GLA exerts any modulatory role on cutaneous eicosanoids, guinea pigs were fed either a control diet containing safflower oil (less than 0.5% GLA) or borage oil, a GLA-rich diet containing 25% GLA. After an 8-week feeding period, epidermal samples from both animal groups were analyzed for fatty acid composition and tissue eicosanoids. Analysis of epidermal neutral lipids and phospholipids in borage oil-fed animals showed a marked increase in GLA and its elongase product, dihomogammalinolenic acid (DGLA). Similarly, analysis of epidermal eicosanoids in the borage oil-fed animals revealed significant increases in the amounts of the 15-hydroxy fatty acid (15-OH-20:3n-6) and prostaglandin PGE1, both metabolites of DGLA. Since these metabolites have anti-inflammatory potential, our results suggest that increased dietary GLA could result in the generation of local anti-inflammatory metabolites thus providing a non-toxic approach to suppression of cutaneous inflammatory skin disorders.
有报道称，含有γ-亚麻酸（GLA）的植物油可能对炎症性皮肤病有有益作用。为了确定膳食中的GLA是否对皮肤类二十烷酸发挥任何调节作用，给豚鼠喂食两种饲料之一：一种是含红花油（GLA含量低于0.5%）的对照饲料，另一种是富含GLA的琉璃苣油饲料（GLA含量为25%）。在8周的喂食期后，对两组动物的表皮样本进行脂肪酸组成和组织类二十烷酸分析。对喂食琉璃苣油的动物的表皮中性脂质和磷脂分析显示，GLA及其延长酶产物二高-γ-亚麻酸（DGLA）显著增加。同样，对喂食琉璃苣油的动物的表皮类二十烷酸分析显示，15-羟基脂肪酸（15-OH-20:3n-6）和前列腺素PGE1的含量显著增加，这两种都是DGLA的代谢产物。由于这些代谢产物具有抗炎潜力，我们的结果表明，增加膳食中的GLA可能会导致局部抗炎代谢产物的产生，从而为抑制皮肤炎症性疾病提供一种无毒方法。
