老年受试者中巨细胞病毒与宿主平衡的受损情况。
Impairment of cytomegalovirus and host balance in elderly subjects.
作者信息
Musiani M, Zerbini M, Zauli D, Cometti G, La Placa M
机构信息
Institute of Microbiology, University of Bologna, Italy.
出版信息
J Clin Pathol. 1988 Jul;41(7):722-5. doi: 10.1136/jcp.41.7.722.
Abstract
The titres of IgG antibody against "late antigens", "immediate early antigens", and "early antigens" induced by cytomegalovirus (CMV) and IgM antibody against "late antigens" induced by CMV were analysed in 67 geriatric subjects by immunocytochemical techniques. The titres obtained were compared with those of an adult control population. Significantly increased titres of IgG antibody against induced antigens and a significant increase in CMV reactivated infections occurred in the elderly compared with control subjects. These findings indicate that the CMV and host balance in the elderly is disturbed, leading to activation of the CMV latent carrier state that follows primary CMV infection.
摘要
采用免疫细胞化学技术分析了67例老年受试者中由巨细胞病毒（CMV）诱导产生的抗“晚期抗原”、“即刻早期抗原”和“早期抗原”的IgG抗体滴度以及由CMV诱导产生的抗“晚期抗原”的IgM抗体滴度。将所得滴度与成人对照人群的滴度进行比较。与对照受试者相比，老年人中诱导抗原的IgG抗体滴度显著升高，CMV再激活感染显著增加。这些发现表明，老年人中CMV与宿主的平衡受到干扰，导致原发性CMV感染后CMV潜伏携带状态的激活。
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