Montanari Micaela, Rossetti Sabrina, Cavaliere Carla, D'Aniello Carmine, Malzone Maria Gabriella, Vanacore Daniela, Di Franco Rossella, La Mantia Elvira, Iovane Gelsomina, Piscitelli Raffaele, Muscariello Raffaele, Berretta Massimiliano, Perdonà Sisto, Muto Paolo, Botti Gerardo, Bianchi Attilio Antonio Montano, Veneziani Bianca Maria, Facchini Gaetano
Progetto ONCONET2.0, Linea Progettuale 14 per L'implementazione della Prevenzione e Diagnosi Precoce del Tumore alla Prostata e Testicolo, Regione Campania, Italy.
Department of Molecular Medicine and Medical Biotechnologies, University of Naples "Federico II", Naples, Italy.
Oncotarget. 2017 May 23;8(21):35376-35389. doi: 10.18632/oncotarget.15686.
Prostate cancer is a main urological disease associated with significant morbidity and mortality. Radical prostatectomy and radiotherapy are potentially curative for localized prostate cancer, while androgen deprivation therapy is the initial systemic therapy for metastatic prostate disease. However, despite temporary response, most patients relapse and evolve into castration resistant cancer.Epithelial-mesenchymal transition (EMT) is a complex gradual process that occurs during embryonic development and/or tumor progression. During this process, cells lose their epithelial characteristics and acquire mesenchymal features. Increasing evidences indicate that EMT promotes prostate cancer metastatic progression and it is closely correlated with increased stemness and drug resistance.In this review, we discuss the main molecular events that directly or indirectly govern the EMT program in prostate cancer, in order to better define the role and the mechanisms underlying this process in prostate cancer progression and therapeutic resistance.
前列腺癌是一种主要的泌尿系统疾病，与显著的发病率和死亡率相关。根治性前列腺切除术和放射治疗对局限性前列腺癌可能具有治愈性，而雄激素剥夺疗法是转移性前列腺疾病的初始全身治疗方法。然而，尽管有暂时的反应，但大多数患者会复发并演变成去势抵抗性癌症。上皮-间质转化（EMT）是一个复杂的渐进过程，发生在胚胎发育和/或肿瘤进展过程中。在此过程中，细胞失去其上皮特征并获得间质特征。越来越多的证据表明，EMT促进前列腺癌的转移进展，并且与干细胞特性增加和耐药性密切相关。在本综述中，我们讨论直接或间接调控前列腺癌EMT程序的主要分子事件，以便更好地确定这一过程在前列腺癌进展和治疗耐药性中的作用及机制。
