对新型喹诺酮类药物高度耐药的弗氏柠檬酸杆菌临床分离株。
Clinical isolate of Citrobacter freundii highly resistant to new quinolones.
作者信息
Aoyama H, Fujimaki K, Sato K, Fujii T, Inoue M, Hirai K, Mitsuhashi S
机构信息
Episome Institute, Gunma, Japan.
出版信息
Antimicrob Agents Chemother. 1988 Jun;32(6):922-4. doi: 10.1128/AAC.32.6.922.
Abstract
About 30% of 150 recent clinical isolates of Citrobacter freundii were resistant to greater than or equal to 3.13 micrograms of norfloxacin and ofloxacin per ml. Study of one quinolone-resistant strain for which the norfloxacin MIC was 100 micrograms/ml suggested that resistance was associated with both an altered A subunit of DNA gyrase and reduction in drug uptake accompanied by a decrease in an outer membrane protein.
摘要
最近从弗氏柠檬酸杆菌中分离出的150株临床菌株中，约30%对每毫升大于或等于3.13微克的诺氟沙星和氧氟沙星耐药。对一株诺氟沙星MIC为100微克/毫升的喹诺酮耐药菌株的研究表明，耐药性与DNA回旋酶A亚基的改变以及药物摄取减少有关，同时外膜蛋白也减少。
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