Ratios of soluble and insoluble dietary fibers on satiety and energy intake in overweight pre- and postmenopausal women.

Fibers' properties impact different mechanisms involved in satiety and energy intake regulation and metabolic outcomes. Evaluate the effect of fiber types and menopausal status on satiety and metabolic responses in overweight women. In a randomized within-subjects design, 19 overweight/obese women [9 premenopausal and 10 postmenopausal] consumed 3 preloads that varied by fiber content and source: 1) 3:1 ratio of soluble:insoluble fiber (SF), 2) 1:3 ratio of soluble:insoluble fiber (IF), 3) no fiber control (NFC). Subjective satiety, cholecystokinin (CCK), glucose, insulin, and triglyceride (TG) were measured for 3 h post-preload followed by in-lab ad libitum test meal and 32 hour food intake monitoring. Significant preload, time and preload by menopausal status interaction was apparent for hunger and fullness ( < 0.05 for both) with SF preload predominantly more satiating in postmenopausal women. CCK and insulin were significantly lower after SF preload ( < 0.0001 for both). Post-preload glucose responses differed by menopausal status: postmenopausal women distinguished between fiber types unlike premenopausal women ( = 0.02). TG was significantly elevated after the IF preload compared to NFC and SF ( = 0.007 and  = 0.008, respectively). dietary recommendations for women during their premenopausal and postmenopausal years can help maximize metabolic and appetite control.