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用于癌症治疗与诊断的下一代超顺磁性氧化铁纳米颗粒。

Next-generation superparamagnetic iron oxide nanoparticles for cancer theranostics.

机构信息

Department of Radiology and Molecular Imaging Program at Stanford (MIPS), Stanford School of Medicine, Stanford, CA, USA.

Department of Radiology and Molecular Imaging Program at Stanford (MIPS), Stanford School of Medicine, Stanford, CA, USA.

出版信息

Drug Discov Today. 2017 Sep;22(9):1421-1429. doi: 10.1016/j.drudis.2017.04.008. Epub 2017 Apr 26.

DOI:10.1016/j.drudis.2017.04.008
PMID:28454771
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5610947/
Abstract

Superparamagnetic iron oxide (SPIO) nanoparticles have been intensively studied for the development of contrast agents in MRI. First-generation SPIO nanoparticles had diagnostic capabilities only, whereas a new generation of SPIO nanoparticle has multifunctional characteristics for combined therapeutic and diagnostic applications. These theranostic nanoparticles hold great potential for image-guided cancer therapies. In particular, polymer-coated theranostic SPIO nanoparticles have enjoyed increasing attention as a result of good biocompatibility, biodegradability and versatile functionality endowed by polymeric matrices. This review provides an overview of recently developed polymer-coated multifunctional SPIO nanoparticles for cancer theranostics and discusses current challenges and future perspectives.

摘要

超顺磁性氧化铁（SPIO）纳米颗粒已被广泛研究，用于开发 MRI 中的造影剂。第一代 SPIO 纳米颗粒仅具有诊断能力，而新一代 SPIO 纳米颗粒具有用于联合治疗和诊断应用的多功能特性。这些治疗诊断纳米颗粒在图像引导癌症治疗方面具有巨大的潜力。特别是，由于聚合物基质赋予的良好的生物相容性、生物降解性和多功能性，聚合物包覆的治疗诊断 SPIO 纳米颗粒受到了越来越多的关注。本文综述了最近开发的用于癌症治疗诊断的聚合物包覆多功能 SPIO 纳米颗粒，并讨论了当前的挑战和未来的展望。

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本文引用的文献

[1]
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Bioeng Transl Med. 2016-6

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Sci Rep. 2016-11-8

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