Alfano Gaetano, Fontana Francesco, Cappelli Gianni
Nephrology Dialysis and Transplant Unit, University Hospital of Modena, Modena, Italy.
Nephron. 2017;136(4):309-317. doi: 10.1159/000457812. Epub 2017 May 4.
The Nexfin monitor is a device used for measuring arterial blood pressure (BP) continuously and noninvasively through finger-cuff technology. Since it was validated against the auscultatory method using a sphygmomanometer, the aim of this study was to test the ability of the Nexfin to evaluate brachial arterial pressure (BAP) in maintenance hemodialysis patients, quantifying accuracy and precision.
Forty hemodynamically stable hemodialysis patients underwent serial measurements of Nexfix arterial pressure (NAP) and BAP, respectively, through Nexfin and oscillometric devices. All BP measurements were recorded before starting hemodialysis.
The mean age of the patients was 68.9 ± 14.9 years with 65% older than 65 years and 30% older than 75; eleven subjects (27%) were diabetic. Vascular calcification, evaluated from the aortic arch to the iliac bifurcation, was detected in 87.5% of patients. Bland-Altman analysis comparing NAP measurements with BAP revealed the following outcomes: a mean bias ± limits of agreements (LA) of 15.3 ± 34.8 mm Hg (29% error) for systolic BP, a mean bias ± LA of -0.9 ± 20.34 mm Hg (32% error) for diastolic BP and a mean bias ± LA of 4.5 ± 21.34 mm Hg (26% error) for mean arterial pressure (MAP). Nexfin had poor precision in the reconstruction of diastolic and mean BP and was extremely inaccurate when evaluating systolic BP. Diabetes mellitus, peripheral neuropathy, and increase in systolic BAP significantly predicted the disagreement in systolic pressure measurement between NAP and MAP, F (3.34) = 10.787, p < 0.005, R2 = 0.488.
The Nexfin does not meet the criteria of interchangeability with oscillometric method in our hemodialysis patients. The negative influence of diabetes, neuropathy, and increase of systolic BAP on the reconstruction of systemic systolic pressure raises concerns about the feasibility of Nexfin in patients with a high prevalence of vasculopathy.
Nexfin监测仪是一种通过指套技术连续、无创测量动脉血压(BP)的设备。自从它与使用血压计的听诊法进行验证以来,本研究的目的是测试Nexfin评估维持性血液透析患者肱动脉血压(BAP)的能力,量化其准确性和精密度。
40名血流动力学稳定的血液透析患者分别通过Nexfin和示波装置进行Nexfix动脉压(NAP)和BAP的系列测量。所有血压测量均在开始血液透析前记录。
患者的平均年龄为68.9±14.9岁,65%的患者年龄大于65岁,30%的患者年龄大于75岁;11名受试者(27%)患有糖尿病。从主动脉弓到髂动脉分叉评估的血管钙化在87.5%的患者中被检测到。将NAP测量值与BAP进行比较的Bland-Altman分析显示了以下结果:收缩压的平均偏差±一致性界限(LA)为15.3±34.8 mmHg(误差29%),舒张压的平均偏差±LA为-0.9±20.34 mmHg(误差32%),平均动脉压(MAP)的平均偏差±LA为4.5±21.34 mmHg(误差26%)。Nexfin在重建舒张压和平均血压方面精度较差,在评估收缩压时极其不准确。糖尿病、周围神经病变和收缩期BAP升高显著预测了NAP和MAP之间收缩压测量的差异,F(3.34)=10.787,p<0.005,R2=0.488。
在我们的血液透析患者中,Nexfin不符合与示波法互换的标准。糖尿病、神经病变和收缩期BAP升高对全身收缩压重建的负面影响引发了对Nexfin在血管病变高发患者中可行性的担忧。