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在聚多巴胺包覆的丝胶蛋白/聚乙烯醇复合薄膜上一步合成银纳米颗粒用于潜在抗菌应用

One-Step Synthesis of Silver Nanoparticles on Polydopamine-Coated Sericin/Polyvinyl Alcohol Composite Films for Potential Antimicrobial Applications.

作者信息

Cai Rui, Tao Gang, He Huawei, Song Kai, Zuo Hua, Jiang Wenchao, Wang Yejing

机构信息

College of Biotechnology, Southwest University, Beibei, Chongqing 400715, China.

State Key Laboratory of Silkworm Genome Biology, Southwest University, Beibei, Chongqing 400715, China.

出版信息

Molecules. 2017 Apr 30;22(5):721. doi: 10.3390/molecules22050721.

DOI:10.3390/molecules22050721
PMID:28468293
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6154384/
Abstract

Silk sericin has great potential as a biomaterial for biomedical applications due to its good hydrophilicity, reactivity, and biodegradability. To develop multifunctional sericin materials for potential antibacterial application, a one-step synthesis method for preparing silver nanoparticles (AgNPs) modified on polydopamine-coated sericin/polyvinyl alcohol (PVA) composite films was developed. Polydopamine (PDA) acted as both metal ion chelating and reducing agent to synthesize AgNPs in situ on the sericin/PVA composite film. Scanning electron microscopy and energy dispersive spectroscopy analysis revealed that polydopamine could effectively facilitate the high-density growth of AgNPs as a 3-D matrix. X-ray diffractometry studies suggested the synthesized AgNPs formed good face-centered cubic crystalline structures. Contact angle measurement and mechanical test indicated AgNPs modified PDA-sericin/PVA composite film had good hydrophilicity and mechanical property. The bacterial growth curve and inhibition zone assays showed the AgNPs modified PDA-sericin/PVA composite film had long-term antibacterial activities. This work develops a new method for the preparation of AgNPs modified PDA-sericin/PVA film with good hydrophilicity, mechanical performance and antibacterial activities for the potential antimicrobial application in biomedicine.

摘要

丝胶蛋白因其良好的亲水性、反应活性和生物降解性，作为一种生物材料在生物医学应用方面具有巨大潜力。为了开发具有潜在抗菌应用的多功能丝胶蛋白材料，本文开发了一种一步合成法，用于制备在聚多巴胺包覆的丝胶蛋白/聚乙烯醇（PVA）复合膜上修饰的银纳米颗粒（AgNPs）。聚多巴胺（PDA）既作为金属离子螯合剂又作为还原剂，在丝胶蛋白/PVA复合膜上原位合成AgNPs。扫描电子显微镜和能量色散光谱分析表明，聚多巴胺作为三维基质能够有效促进AgNPs的高密度生长。X射线衍射研究表明，合成的AgNPs形成了良好的面心立方晶体结构。接触角测量和力学测试表明，AgNPs修饰的PDA-丝胶蛋白/PVA复合膜具有良好的亲水性和力学性能。细菌生长曲线和抑菌圈试验表明，AgNPs修饰的PDA-丝胶蛋白/PVA复合膜具有长期抗菌活性。这项工作开发了一种新方法，用于制备具有良好亲水性、力学性能和抗菌活性的AgNPs修饰的PDA-丝胶蛋白/PVA膜，以用于生物医学中的潜在抗菌应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b48/6154384/d1b823be0462/molecules-22-00721-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b48/6154384/0175971fce92/molecules-22-00721-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b48/6154384/0dbdd11ff94c/molecules-22-00721-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b48/6154384/0d8ee16b5b65/molecules-22-00721-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b48/6154384/0b3c462aff58/molecules-22-00721-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b48/6154384/c2ef8e9bad09/molecules-22-00721-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b48/6154384/01885058942d/molecules-22-00721-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b48/6154384/c55d1bcba160/molecules-22-00721-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b48/6154384/020dd4207a0b/molecules-22-00721-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b48/6154384/d1b823be0462/molecules-22-00721-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b48/6154384/0175971fce92/molecules-22-00721-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b48/6154384/0dbdd11ff94c/molecules-22-00721-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b48/6154384/0d8ee16b5b65/molecules-22-00721-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b48/6154384/0b3c462aff58/molecules-22-00721-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b48/6154384/c2ef8e9bad09/molecules-22-00721-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b48/6154384/01885058942d/molecules-22-00721-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b48/6154384/c55d1bcba160/molecules-22-00721-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b48/6154384/020dd4207a0b/molecules-22-00721-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b48/6154384/d1b823be0462/molecules-22-00721-g009.jpg

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