Singh Priti, Pandey Shailendra Kumar, Singh Jyoti, Srivastava Sameer, Sachan Sadhana, Singh Sunil Kumar
1Department of Biotechnology, Motilal Nehru National Institute of Technology, Allahabad, Uttar Pradesh 211004 India.
2Department of Chemical Engineering, Motilal Nehru National Institute of Technology, Allahabad, Uttar Pradesh 211004 India.
Nanomicro Lett. 2016;8(3):193-203. doi: 10.1007/s40820-015-0077-x. Epub 2015 Dec 21.
Electrochemical biosensor holds great promise in the biomedical area due to its enhanced specificity, sensitivity, label-free nature and cost effectiveness for rapid point-of-care detection of diseases at bedside. In this review, we are focusing on the working principle of electrochemical biosensor and how it can be employed in detecting biomarkers of fatal diseases like cancer, AIDS, hepatitis and cardiovascular diseases. Recent advances in the development of implantable biosensors and exploration of nanomaterials in fabrication of electrodes with increasing the sensitivity of biosensor for quick and easy detection of biomolecules have been elucidated in detail. Electrochemical-based detection of heavy metal ions which cause harmful effect on human health has been discussed. Key challenges associated with the electrochemical sensor and its future perspectives are also addressed.
电化学生物传感器因其特异性增强、灵敏度高、无需标记以及成本效益高,有望在床边快速进行即时医疗检测,在生物医学领域具有广阔前景。在本综述中,我们重点关注电化学生物传感器的工作原理,以及它如何用于检测癌症、艾滋病、肝炎和心血管疾病等致命疾病的生物标志物。详细阐述了可植入生物传感器开发的最新进展,以及在制造电极过程中探索纳米材料以提高生物传感器对生物分子的快速简便检测灵敏度的情况。还讨论了基于电化学检测对人体健康产生有害影响的重金属离子的情况。同时也探讨了与电化学传感器相关的关键挑战及其未来前景。