Departments of Community Health Sciences and Paediatrics, University of Calgary, Calgary, AB, Canada.
Faculty of Nursing, University of Alberta, Edmonton, AB, Canada.
Patient. 2017 Dec;10(6):687-700. doi: 10.1007/s40271-017-0244-x.
Discrete choice experiments are increasingly used to assess preferences for vaccines and vaccine service delivery.
To synthesize and critically assess the application of discrete choice experiments in childhood/adolescent vaccines, to describe how discrete choice experiments have been applied to understand preferences, and to evaluate the use of discrete choice experiment data to inform estimates of vaccine uptake.
We conducted a systematic review of six electronic databases. Included studies were discrete choice experiments and conjoint analyses published from 2000 to 2016 related to childhood/adolescent vaccines where respondents were parents, children/adolescents, or service providers. Validity assessment was used to assess study quality and risk of bias.
In total, 27 articles were included, representing 21 different studies. A majority of articles were published between 2011 and 2016. Vaccines studied included human papillomavirus (24%), influenza (19%), meningococcal vaccines (14%), childhood vaccines (14%), hypothetical vaccines (10%), hepatitis B (5%), and diphtheria, tetanus, pertussis, hepatitis B, poliomyelitis, and Haemophilus influenzae type b (5%). Most studies assessed parent preferences (67%). The most common attributes were risk (24%), degree/duration of protection (21%), and cost (15%). Commonly reported outcome measures were estimates of uptake (33%), willingness-to-pay (22%), and other marginal rates of substitution (14%). Validity assessments yielded high scores overall. Areas of weakness included low response rates, inefficient experimental design, and failure to conduct formative qualitative work and a pilot of the discrete choice experiment.
This is the first systematic review of childhood/adolescent vaccine-related discrete choice experiments. In future, special attention should be paid to ensuring that choice context and discrete choice experiment design are compatible to generate reliable estimates of uptake.
离散选择实验越来越多地被用于评估疫苗和疫苗服务提供的偏好。
综合评估离散选择实验在儿童/青少年疫苗中的应用，描述如何应用离散选择实验来理解偏好，并评估离散选择实验数据在提供疫苗接种率估计中的应用。
我们对六个电子数据库进行了系统综述。纳入的研究为 2000 年至 2016 年间发表的与儿童/青少年疫苗相关的离散选择实验和联合分析研究，受访者为父母、儿童/青少年或服务提供者。使用有效性评估来评估研究质量和偏倚风险。
共纳入 27 篇文章，代表 21 项不同的研究。大多数文章发表于 2011 年至 2016 年之间。研究的疫苗包括人乳头瘤病毒（24%）、流感（19%）、脑膜炎球菌疫苗（14%）、儿童疫苗（14%）、假设疫苗（10%）、乙型肝炎（5%）、白喉、破伤风、百日咳、乙型肝炎、脊髓灰质炎和流感嗜血杆菌 b 型（5%）。大多数研究评估了家长的偏好（67%）。最常见的属性是风险（24%）、保护程度/持续时间（21%）和成本（15%）。常用的报告结果测量是接种率的估计值（33%）、支付意愿（22%）和其他边缘替代率（14%）。总体而言，有效性评估得分较高。弱点包括低响应率、低效的实验设计以及未能进行形成性定性工作和离散选择实验的试点。
这是第一个关于儿童/青少年疫苗相关离散选择实验的系统综述。在未来，应特别注意确保选择背景和离散选择实验设计兼容，以生成可靠的接种率估计值。
