镍催化烯烃通过自由基环化进行的双组分还原双碳官能化反应。
Ni-catalyzed two-component reductive dicarbofunctionalization of alkenes via radical cyclization.
作者信息
Kuang Yulong, Wang Xuefeng, Anthony David, Diao Tianning
机构信息
Department, New York University, 100 Washington Square E., New York, NY 10003, USA.
出版信息
Chem Commun (Camb). 2018 Mar 6;54(20):2558-2561. doi: 10.1039/c8cc00358k.
PMID:29465735
Abstract
A reductive dicarbofunctionalization reaction of alkenes has been developed and applied to the preparation of substituted carbo- and heterocycles. The reaction conditions avoid the use of air-sensitive organometallic reagents, and are compatible with a broad range of bromo-electrophiles and a wide variety of substituents to give cyclic products in excellent yields.
摘要
烯烃的还原双碳官能团化反应已被开发并应用于制备取代的碳环和杂环化合物。该反应条件避免使用对空气敏感的有机金属试剂，并且与多种溴代亲电试剂和各种各样的取代基兼容，能以优异的产率得到环状产物。
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