Li Yuanjun, Miara Hamza, Ouyang Pingbo, Jiang Bing
Department of Ophthalmology, Hunan Clinical Research Center of Ophthalmic Disease, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Department of Ophthalmology, Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, The Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
J Ophthalmol. 2018 Jan 31;2018:3490962. doi: 10.1155/2018/3490962. eCollection 2018.
To determine the correlations between peripapillary vessel density, retinal nerve fibre layer (RNFL) thickness, and myopic indices at retina quadrants with optical coherence tomography angiography (OCTA) in Chinese.
Fifty-six subjects with a mean spherical equivalent (MSE) of -3.63 ± 0.29 D were included. Peripapillary RNFL thickness and retinal vessel density in four sectors (superior, nasal, inferior, and temporal quadrants) were determined by OCTA, and correlations of the main outcomes were analyzed.
Negative correlations were found between the peripapillary RNFL thickness and axial length (AL) at superior ( = -0.335, = 0.001) and inferior ( = -0.551, < 0.001) quadrants. There was a significant positive correlation with spherical equivalent (SE) at the corresponding quadrants as well as at the nasal quadrant ( = 0.339, = 0.001; = 0.379, < 0.001; and = 0.209, = 0.039, resp.). Peripapillary retinal vessel density was also negatively correlated with AL at the nasal quadrant ( = -0.392, < 0.001), and only at the nasal quadrant, there was a positive correlation between the peripapillary vessel density and SE ( = 0.319, = 0.001).
The degree of myopia and elongation of AL were negatively correlated with peripapillary RNFL thickness at superior and inferior quadrants and with peripapillary retinal vessel density at the nasal quadrant.
运用光学相干断层扫描血管造影（OCTA）技术，在中国人群中确定视乳头周围血管密度、视网膜神经纤维层（RNFL）厚度与视网膜象限近视指标之间的相关性。
纳入56名平均球镜等效度数（MSE）为-3.63±0.29D的受试者。通过OCTA测定四个象限（上方、鼻侧、下方和颞侧）的视乳头周围RNFL厚度和视网膜血管密度，并分析主要结果的相关性。
上方象限（r=-0.335，P=0.001）和下方象限（r=-0.551，P<0.001）的视乳头周围RNFL厚度与眼轴长度（AL）呈负相关。在相应象限以及鼻侧象限，视乳头周围RNFL厚度与球镜等效度数（SE）呈显著正相关（分别为r=0.339，P=0.001；r=0.379，P<0.001；r=0.209，P=0.039）。鼻侧象限的视乳头周围视网膜血管密度也与AL呈负相关（r=-0.392，P<0.001），且仅在鼻侧象限，视乳头周围血管密度与SE呈正相关（r=0.319，P=0.001）。
近视程度和AL延长与上方和下方象限的视乳头周围RNFL厚度以及鼻侧象限的视乳头周围视网膜血管密度呈负相关。
